Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Secondary Endpoints"”.
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BLINDED EVALUATIONS OF EFFECT SIZES IN CLINICAL TRIALS: COMPARISONS BETWEEN BAYESIAN AND EM ANALYSES
… involves careful selection of the primary and secondary efficacy endpoints. The 2010 draft FDA guidance on adaptive designs acknowledges possible study design modifications, such as selection and/or order of secondary endpoints, in addition to sample size re-estimation. It is essential for the …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
… Primary endpoint was time to ALT < 100 U/L; secondary endpoints included length of hospital stay and 8-week mortality. We described outcomes of ATT rechallenge following AT-DILI. We quantified miR-122 and ALT concentrations before and after infusion of NAC/placebo, and explored the effect of …
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
… ablate naturally occurring canine brain tumors. Secondary endpoints included characterization of magnetic resonance imaging (MRI) responses to histotripsy treatment, and exploratory immunogenomic tumor response analyses. Methods: The study design utilized a treat and resect paradigm, where tumors …
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EFFECTS OF STRESS HYPERGLYCEMIA ACCORDING TO DIABETICSTATUS IN PATIENTS WITH ST-ELEVATION MYOCARDIALINFARCTION AND ITS RELATIONSHIP WITH CARDIAC CELL INJURYAND MITOCHONDRIAL DAMAGE: A TRANSLATIONAL APPROACH
… acute-pulmonary-edema, and shock was the secondary endpoint. Results: 100 STEMI patients with DM and 100 without were included. IS was 25gr and 19gr and the secondary endpoint occurred in 21% and 8% of patients with and without DM, respectively (p=0.02 and p=0.01, respectively). The A/C …
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Daily Nocturnal Melatonin Supplementation in Perimenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Study Examining the Effects of Melatonin on Bone Health and Quality of Life
… of nightly melatonin supplementation on primary endpoints of bone health and secondary endpoints of quality of life in perimenopausal women. </p><p> Methods: A total of 18 perimenopausal women were randomized to receive melatonin, 3 mg p.o., (n=13) or placebo (n=5) nightly for six months. Bone …
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Development of a Medication Override Process for Obstetrics and Newborn Care at a Large Academic Medical Center
… units pre- and post-intervention. The secondary endpoints were hospital-wide overrides, override rates for the most common medications overridden in the L&D/nursery, and utilization of the inventory function in the L&D/nursery units. A chi-squared test was utilized to determine …
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IMPACT OF SARS-COV-2 RESPIRATORY INFECTION ON CLINICAL OUTCOMES AND NEED FOR NON-INVASIVE VENTILATORY SUPPORT IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A SINGLE-CENTER, PROSPECTIVE, OBSERVATIONAL STUDY
… without SARS-CoV-2 infection. Major secondary endpoints included the overall risk of ARF and its stratification according to severity and consequent respiratory support needed. Mortality in the SARS-CoV-2 cohort was also compared to the control group. 238 COPD patients admitted to …
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Optimization of Medication Delivery Robot Use Using Lean Methodology in a Veterans Affairs Academic Medical Center
… medication delivery time to the nursing units. Secondary endpoints include the volume of missing doses and cost-savings post implementation. METHODS: Our pharmacy technology project management incorporated principles of lean and six sigma methodologies to refine value-added processes and …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… HSPCs from patients meeting the primary or secondary endpoints (tamoxifen responders) were highly enriched with specific molecular pathways such as integrated stress response (ISR), proinflammatory signalling, mitochondrial activity and proteotoxic stress at baseline, implying a predictable …
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Investigating a novel combination treatment of androgen deprivation therapy, pelvic external beam radiotherapy and radium-223 dichloride in the management of hormone sensitive prostate cancer metastatic to bone
… in 37 fractions to pelvic lymph nodes). Primaryendpoints were recruitment, toxicity (CTCAE scoring), and quality of life(patient reported EPIC scoring). Secondary endpoints were radiological responsewith whole body (wb)MRI, PSA/ALP response and time to first symptomaticskeletal event (SSE). We …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
… but that are respectively the primary and secondary endpoints in clinical trials for IPF (Spagnolo et al. 2013) to monitor patients during the treatments. Additionally, also some emerging biomarkers currently under evaluation in the clinical setting were explored in the model. Finally, we …
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Assessing the Impact of a Unit-Based Clinical Pharmacist on Antimicrobial Use in a Level I Trauma Center – A Pilot Study
… of antibiotics from IV to PO within 3 days and a secondary endpoint of days of therapy by a de-escalation of antimicrobial use within 48 hours of lab results. Results A total of 240 patients receiving antibiotics were randomly selected during the study period. The 6-week period pre-implementation …
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Cellular and molecular mechanisms of response to, and recurrence following, breast radiotherapy
… treatment followed by breast surgery; clinical secondary endpoints including mastectomy rate, peri/post-operafve complicafons, pathological response to treatment and late normal fssue toxicity. Translational opportunities were built into the trial protocol: sequential tumour research biopsies …