Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Second-line therapy"”.
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Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
Purpose: Delaying chemotherapy remains a vital goal in therapeutic management of HR+/HER2– metastatic breast cancer (MBC). However, recent reports continue to highlight substantially high chemotherapy utilization in earlier therapy lines. In this study, we explored the impact of cyclin-dependent …
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Understanding the Genome-Wide Response of Streptomyces coelicolor to the Glycopeptide Antibiotic Teicoplanin
… and teicoplanin are clinically important as a second-line therapy to treat nosocomial infections caused by Gram-positive pathogens. Glycopeptide antibiotics universally target the terminal residues, D-Alanyl-D-Alanine on the cell wall peptidoglycan intermediate lipid II, interfering with …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… cases, subsets of SCLC are driven by specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The expression of various MYC family members leads to further inter-tumor heterogeneity. Despite this heterogeneity in SCLC, the current treatment for SCLC is …
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Temozolomide and Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor
… gemcitabine based, or paclitaxel chemotherapy as first- or second-line therapy, the overall RECIST response rate was 0%. Most patients achieved a brief duration of disease stabilization on chemotherapy, with median progression-free survival (PFS) period of 4.6 months. For the 14 …
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Outcome and prognostic factors of palliative chemotherapy for non-small cell lung cancer patients at single institution: 2002-2011
… cancer patients who received palliative chemotherapy, overall survival, and factors that affect the survival rates. The study subjects were 402 non-small cell lung cancer patients who received palliative chemotherapy during 10 years from January 2002 to December 2011 at a university hospital. …
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Toxicities associated with antiretroviral treatment of HIV-1
… of the two ART by examining CVD biomarkers. The second identified baseline predictors of limb fat recovery. A final study identified specific HLA genotypes associated with body composition changes. The final chapters of the thesis examined ART toxicities in HIV participants failing their …
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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
… the treatment for TB with the standard first and second-line therapy is becoming increasingly difficult. Therefore, there is an urgent need to find new anti-TB drugs as combination partners of existing and experimental classes of antimicrobial agents to shorten and simplify the treatment of MDR or …
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Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)
… surgical resection and/or cytotoxic drugs. Chemotherapy has resulted in a modest increase (median survival of 8 months with chemotherapy vs median survival of 5.7 months for patients without chemotherapy) in the overall survival of patients. Advances have been made in understanding the molecular …
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biological treatment options of multiple myeloma
… particular cell receptors. Daratumumab is a therapy that targets CD38, the primary receptor found on normal plasma cells and multiple myeloma cells. Alternatively, another potential target on the surface of cells is SLAMF7, sometimes referred to as CS1, which is specifically recognized by …
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Evaluation of the costs of managing cutaneous adverse drug reactions to first-line TB therapy in South African TB patients
… hospitalisation. There are no standardised guidelines for managing CADR to TB therapy. Current practice in South Africa involves drug rechallenge, a process, which aims to identify the offending drug and modify the treatment regimen. This practice can carry significant risks that need to be …