Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Second Messenger Systems"”.
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Cellular mechanisms of angiotensin release
… and ligands that stimulate or inhibit second messenger systems in an attempt to understand how the release of ANG is regulated.
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… perturbation of the PI3K/Akt and MAPK/Erk second messenger systems and dysregulation of immediate early genes. The mechanistic insights from these human models may aid the discovery of novel pharmaceutical targets to treat OUD or prevent long-term consequences of drug exposure.</p>
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Regulation of Estradiol-17beta Synthesis by Small Follicles of the Domestic Hen Ovary
… PKC system. The interaction of PKA and PKC second messenger systems may be needed for the fine-tuned regulation of E$\sb2$ production.
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol …
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Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
… receptors (GPCRs) and the extensive second messenger systems associated with their activation has ushered in an enormously productive period in drug discovery. The extent to which around one-third of FDA-approved medications target GPCRs. Predictably, small molecule allosteric …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
Dopaminergic systems regulate many brain functions and dysfunction of dopaminergic neurotransmission is thought to underlie numerous disorders, including schizophrenia, attention deficit hyperactivity disorder (ADHD), depression and Alzheimer’s disease. In the hippocampus, a dopaminergic projection …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… cyclic GMP-AMP (cGAMP), as a novel eukaryotic second messenger generated by DNA stimulated or DNA virus infected cells. cGAMP contains a unique phosphodiester linkage combination (both 2'-5' and 3'-5'), for which we referred to it as 2'3'-cGAMP. 2'3'-cGAMP bound to STING with nanomolar affinity …
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Characterisation of novel compounds as antagonists of protease-activated receptor-2 (PAR2)
… leading to the coupling to a number of defined second messenger systems though G-protein engagement. Early signalling events such as the mobilisation of intracellular Ca2+ and downstream cascades including ERK MAP kinase mediate an array of cellular effects stimulated through PAR2. Many studies …
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The regulation of luteinizing hormone exocytosis in α-toxin permeabilized sheep anterior pituitary cells
… interaction of the cAMP, PKC and Ca²⁺ second messenger systems is of importance in the mechanism of GnRH-stimulated LH exocytosis. When permeabilized cells were equilibrated for prolonged periods in the absence of MgATP, Ca²⁺-stimulated LH exocytosis declined. The time course of the …