Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"SecY"”.
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Structural Studies of Protein Transport
… families of protein-conducting channels: SecY and Oxa1. First, it presents an evolutionary analysis of SecY. This leverages the fact that SecY is a pseudodimer of two duplicated halves, which makes it possible to infer certain characteristics of those halves’ common ancestor, termed …
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Computational investigation of protein translocation and membrane insertion
… crystal structure of an archaeal translocon, the SecY complex, revealed a channel tightly closed by two elements: a small ""plug"" domain blocking the periplasmic region of the channel and a pore ring composed of six hydrophobic residues acting as a constriction point at the channel's center. …
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Untersuchungen zum Integrations- und Translokationsmodus des Sec-Translokons in Escherichia coli
… laterale Oeffnung zur Lipidphase voraussetzt. SecY und SecE sind die fuer beide Funktionen essentiellen Komponenten des bakteriellen Translokons. Fuer die Translokasefunktion rekrutiert das Translokon SecG und bildet die funktionelle Einheit fuer die SecA/SecB-abhaengige Proteintranslokation. …
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Epidemiologia molecular de lepstospiras patogênicas no Brasil: uma abordagem integrativa multi-hospedeiros e multirregional
… diagnóstico por PCR, tipificação baseada no gene secY, análises filogenéticas e de rede haplotípica, além da curadoria e compilação de extensos bancos de dados genéticos e metadados ecológicos. As análises integradas evidenciaram ampla diversidade ecológica de Leptospira spp. patogênicas, …
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In vitro studies on the SecA involvement in the assembly of an integral membrane protein with large hydrophilic domain
… of inner membrane proteins takes place via the SecYEG-translocon. The targeting pathways of secretory and membrane proteins to the SecYEG translocon however, are different. Integral membrane proteins are co-translationally targeted by signal recognition particle (SRP) and its receptor FtsY, …
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Construction of an efficient secretion system for recombinant proteins in Bacillus subtilis
… channel translocon complex composed of the SecYEG proteins. Based on the known characteristics of both pathways, the goal of this PhD project was to construct an efficient secretion system for recombinant proteins in Bacillus subtilis using an a-amylase as a reporter enzyme, which is …
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Investigating the mechanisms of protein synthesis using multi-resolution structural data
The ribosome is a complex, dynamic molecular machine responsible for protein synthesis in all cells according to the genetic information. Recent breakthroughs in ribosome crystallography culminated with the 2009 Nobel Prize in Chemistry. Concomitantly, advances in cryo-electron microscopy (cryo-EM) …