Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Screening System"”.
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Validating and Refining a Locally Developed Universal Screening System in High School Mathematics
… This study evaluated the effectiveness of the screening system currently in use at one urban Texas public high school and compared its effectiveness to alternate screening systems that used the same resources but with different cut scores. The goal for the screener was to accurately identify …
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A high-throughput antiepileptic drug screening system based on chemically Induced zebrafish behavioral model
… the largest worldwide impacts among all nervous system diseases expect for stroke and dementia, is a group of long-term neurological disorders characterized by epileptic seizures. AED medications are the mainstay for epileptic seizure management. However, the existing AEDs cannot fit the needs …
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Oxidativer Stress- assoziierter neuronaler Zelltod und die Identifikation neuroprotektiver Gene durch ein neuartiges Screening-System
… dieser Arbeit wurden mit Hilfe einer neuartigen Screening-Methode im Hochdurchsatz-Maßstab Gene identifiziert, welche einen Schutz vor dem bei Morbus Alzheimer assoziierten oxidativen Nervenzelltod vermitteln können. Dazu wurde jeder Klon einer cDNA Kollektion einzeln in klonale hippokampale …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… A global effort to carry out phenotypic screening in live parasite assays has identified many promising hit compounds, but elucidating the targets of these compounds, often a necessary step in the hit-to-lead development process, has been slow. This is because target identification has …
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Developing a 2-Phase Screening System to Assess the in vitro and in vivo Stability of Engineering Native Seed Storage Proteins
… thesis describes the development of a 2-phase screening system that facilitates protein engineering of native 11S globulins by assessing the ability of stable site-directed variants to accumulate in seeds. Phase I employs E. coli as an expression system to assess the thermodynamic stability of …
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Development of a new screening system for the identification of RNF43-related genes and characterisation of other PA-RING family members.
… Here, I describe the development of a new screening strategy which combines CRISPR/Cas9 technology with 3D-intestinal organoid culture for the identification of novel molecular interactors of RNF43. Overall, this study and the technology developed provide a tool to enable the detailed …
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Clinical-view versus ELM: an investigation into image types in the context of skin lesion screening
… this most visible of cancers. Current automated systems for detecting melanoma analyse images of skin lesions for relevant image features, and classify the images based on those features. There are two types of image available to be used in such systems, Clinical-view or Epiluminescent microscopy …
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Automatic 3D surface area measurement for vitiligo lesions
… techniques, we develop an automated skin lesion screening system (VLAMS) that can be widely adopted in clinics. VLAMS is tested using clinical medical data. Results show VLAMS can consistently segment target lesion region and accurately measure lesion area of any skin surface.
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The origins of state security screening in Canada
… the Canadian government to initiate a security screening program for civil servants and armed forces personnel. This program was an attempt to discern the political opinions, behaviour and trustworthiness of people in positions of trust both inside the state and outside. This thesis rewrites the …
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Development of high throughput screening systems for the efficient production of antibody fragments in Escherichia coli
… dissertation describes the development of novel screening systems for isolating antibody fragments and alternatively, E. coli genes, that facilitate expression in E. coli. In the first part of this work, we have developed a screening system for isolating Fab mutants exhibiting 4~5 fold higher …
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Platforms for Biological Control
… and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening …
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Design of water-splitting photocatalysts by first principles computations
… the desired accuracy for high throughput screening at an acceptable computational cost. We have designed a three-tier first principles high throughput screening system to identify new water-splitting photocatalysts by examining the phase stability, band gap and band edge positions of the …
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Microfluidic in vivo laser microsurgery screen for identification of compounds enhancing neural regeneration
… significant for therapeutics of central nervous system injuries and neurodegenerative disorders. C. elegans is a widely studied model organisms due to their fully mapped neural network of 302 neurons and amenable genetics. Their small size and short life cycle allows for rapid studies to be …
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An Evaluation of Different Risk Ranking Systems for Contaminated Sites
Risk ranking systems for contaminated sites have been developed by different jurisdictions with similar purpose, but it is not clear whether they provide results that are comparable. The United States’ Preliminary Assessment (PA) system, Sweden’s Methods for Inventories of Contaminated Sites (MICS) …
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An Operations Research approach to aviation security
… we address the usefulness of passenger pre-screening systems to select potentially high-risk passengers for additional scrutiny. We model the probability that a terrorist boards an aircraft with weapons, incorporating deterrence effects and potential loopholes. We find that despite the …
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Identification of HIV protease mutants with improved specificities toward an Alzheimer's Disease associated peptide sequence
… applications. We used this E. coli-based screening system to isolate multiple HIV protease mutants with improved proteolytic specificities and activities toward an octapeptide taken from the beta-amyloid peptide (Abeta) implicated in Alzheimer's Disease. Quantitative Western blotting of E. …
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The Development of Genetic Tools for Protein Characterization and Genetic Engineering in the Acetic Acid Bacterium Gluconobacter Oxydans
… been constructed: a fluorescent-protein based screening system, a surface display system, and an inducible promoter system. The results of the construction of these three tools for use in G. oxydans and initial analyses of the effectiveness within the host are presented.
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High-throughput vertebrate total analysis/screening platform
High-throughput screening (HTS) is seen as one of the most promising technologies to facilitate biomedical studies and pharmaceutical discoveries. Although large varieties of in vitro HTS technologies have opened great opportunities, the speed of improvement has been limited by lack of advanced …
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Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α
… anti-breast cancer drugs. However, the existing screening system is inefficient and time-consuming despite the extremely large amount of small molecule compounds in database currently available, and thereby hindering the effort for selecting new and effective anti-cancer drugs.</p> <p>The …
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