Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Scorpion venom"”.
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The identification and characterisation of antimicrobial peptides from snake and scorpion venom.
… action, and selectivity to prokaryotic membranes.Venoms are an under exploited source of AMPs, in this thesis AMPs have been identified, biologically characterised and their mechanism investigated. From snake venom two novel AMPs (6-7KDa) along with four potential phospholipase A2 (PLA2) proteins …
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Behavioral and Physiological Ecology of Scorpion Venom Expenditure: Stinging, Spraying, and Venom Regeneration
… I reviewed the functional aspects of venom from a behavioral perspective to develop a comprehensive understanding of the behavioral ecology of venom. To explore the behavioral and physiological ecology of venom expenditure by scorpions, I conducted four studies of the medically …
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The discovery identification and characteristion of antimicrobial peptides from amphibian frogs and scorpion venom
… the amphibian defensive skin secretions and scorpion venom have proven to be great treasury for novel functional peptide discovery and these have become attractive targets for innovative drug development. In Chapter 3, an antimicrobial peptide (Phylloseptin-PHa) from the phylloseptin family …
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Characterisation, bioactivity evaluation and rational modification of bioactive peptides from frog skin secretion and scorpion venom
… bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to …
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The membrane-active antimicrobial peptide from frog skin and scorpion venom: from mechanistic insight to design
… peptides from the frog skin secretions and scorpion venoms. In chapter 3, studies focused on a novel brevinin-1 type peptide, brevinin-1GHd, found in frog Hylarana guentheri, skin secretion. Functional screening revealed that brevinin-1GHd exhibited potent antimicrobial, antibiofilm, and …
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An antimicrobial peptide QUB-1925 from scorpion venom of Androctonus bicolor: molecular cloning of biosynthetic precursor-encoding cDNA and bioactivity study
… the prominent biological diversity and potency, venoms of scorpion have attached to a starting point for drug discovery. This thesis focused on a novel antimicrobial peptide discovered from Androctonus bicolor. The QUB-1925 precursor-encoding cDNA was cloned by “shotgun” cloning of the …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
Scorpion venom contains a variety of peptides exerting broad bioactivities. In this thesis, QUB-1761, a non-disulphide bridged peptide (NDBP), was discovered in the venom of the Brazilian yellow scorpion, Tityus serrulatus (T. serrulatus). The peptide was identified through molecular cloning by …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… vitro </em>specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of <em>e</em>xtracellular <em>m</em>atrix <em>m</em>etalloproteinase <em>in</em>ducer (EMMPRIN; Basigin) isoform 2, toward U87 GBM and MSU 1.1 human …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… polypeptide derived from Leiurus quinquestriatus scorpion venom, has shown selective binding to GBM cells, making it a promising candidate for diagnostic applications and improving tumor visualization. However, the molecular targets of Ctx are unclear, with Matrix Metalloproteinase-2 (MMP-2) and …