Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Scorpion"”.
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The identification and characterisation of antimicrobial peptides from snake and scorpion venom.
… candidate for future drug development. From scorpion venom, three AMPs (1-4 KDa) have been biologically characterised, one of which, Smp43, is postulated to have a di-helical structure and exhibits good antimicrobial activity especially against Gram positive organisms (4-64 ug/ml) and …
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The mechanism of action of the scorpion toxin, chlorotoxin, a bioinformatics approach
Glioblastoma is a very invasive and metastatic cancer with low patient survival-rate and high resistance to current treatment. Matrix metalloproteinase 2 (MMP2) is upregulated in glioblastoma multiforme (GBM) and its high expression is directly correlated with invasion and metastasis of GBM cells. …
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Behavioral and Physiological Ecology of Scorpion Venom Expenditure: Stinging, Spraying, and Venom Regeneration
… physiological ecology of venom expenditure by scorpions, I conducted four studies of the medically significant Buthid scorpion <em>Parabuthus transvaalicus</em>. The first two experiments revealed that scorpions regulate their venom expenditure during defensive stinging and squirting in the …
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The discovery identification and characteristion of antimicrobial peptides from amphibian frogs and scorpion venom
… the amphibian defensive skin secretions and scorpion venom have proven to be great treasury for novel functional peptide discovery and these have become attractive targets for innovative drug development. In Chapter 3, an antimicrobial peptide (Phylloseptin-PHa) from the phylloseptin family …
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Characterisation, bioactivity evaluation and rational modification of bioactive peptides from frog skin secretion and scorpion venom
… bamboo leaf frog - Odorrana versabilis, and the scorpion Androctonus bicolor. In chapter 3 a novel Bowman-Birk type protease inhibitor (ranacyclin-NF) was identified in the skin secretion of Pelophylax nigromaculatus. Besides studying its potential applications, two analogues were designed to …
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The membrane-active antimicrobial peptide from frog skin and scorpion venom: from mechanistic insight to design
… peptides from the frog skin secretions and scorpion venoms. In chapter 3, studies focused on a novel brevinin-1 type peptide, brevinin-1GHd, found in frog Hylarana guentheri, skin secretion. Functional screening revealed that brevinin-1GHd exhibited potent antimicrobial, antibiofilm, and …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
Scorpion venom contains a variety of peptides exerting broad bioactivities. In this thesis, QUB-1761, a non-disulphide bridged peptide (NDBP), was discovered in the venom of the Brazilian yellow scorpion, Tityus serrulatus (T. serrulatus). The peptide was identified through molecular cloning by …
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An antimicrobial peptide QUB-1925 from scorpion venom of Androctonus bicolor: molecular cloning of biosynthetic precursor-encoding cDNA and bioactivity study
… biological diversity and potency, venoms of scorpion have attached to a starting point for drug discovery. This thesis focused on a novel antimicrobial peptide discovered from Androctonus bicolor. The QUB-1925 precursor-encoding cDNA was cloned by “shotgun” cloning of the venom-derived cDNA …
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Studies of luminescent materials including novel preparation of phosphors
… is reported in the first part of the appendix. Scorpion and horseshoe crab emission spectra have been obtained, and in the case of the scorpion samples it is possible to examine emission spectra at different wavelengths.
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A Preliminary Investigation Comparing Craniofacial Metric Measurements and 3D Virtual Measurements
… on the human skull. I used a Polhemus Fast Scan Scorpion scanner to scan 8 skulls and evaluated the standard 24 metric measurements in Delta analysis software in comparison to standard metric measurements. The scanned measurements were then compared to the standard metric measurements using the …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… vitro </em>specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of <em>e</em>xtracellular <em>m</em>atrix <em>m</em>etalloproteinase <em>in</em>ducer (EMMPRIN; Basigin) isoform 2, toward U87 GBM and MSU 1.1 human …
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Recombinant Expression In Pichia pastoris System Of The Potassium Channel Inhibitor Peptide, Ts6.
… from Tityus serrulatus venom (a Brazilian scorpion) is composed of 40 amino acid residues, four disulfide bonds, and a molecular weight of 4.5 kDa. In the scope of this research, we used X-33 Pichia pastoris yeast which produced Ts6 extracellularly in substantial amount. The plasmid vector …
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Predation of Ringed Salamander Larvae, Ambystoma Annulatum
… hour period instead of five. Ranatra (water scorpion) and larger A. annulatum larvae were added as predators. A two-way ANOVA showed significant main effects of predator, (P < 0.0001), and prey size (P < 0.0001), and a significant interaction (P < 0.0001). Tukey's multiple comparison tests …
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An evaluation of computer assisted skull re-assembly using hand held and automated laser scanners
… 3D models produced by a hand held laser scanner (Scorpion FASTSCAN by Polhemus) and one model produced by an automated, stationary laser scanner (Minolta by Hyperfocal) to re-assemble 5 skulls using a computer modelling program (Freeform Modelling). Hand held scanning, model production and quality …
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Explaining data in visual analytic systems
… a browser-based visual exploration tool; Scorpion, a set of algorithms that describes the subset of an outlier's input records that "explain away" the anomalous value; and SubZero, a system to track and retrieve the input records that contributed to output records of a complex workflow. …
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High-Resolution Seismic Characterization of Shallow Sedimentary Structure for Freshwater Resources and Karstic Voids
… of two impulsive borehole seismic sources, Scorpion and Ballard, is rigorously examined at a Gulf of Mexico coastal site. Both sources are evaluated in crosswell and reverse vertical seismic profile (RVSP) configurations. The study reveals distinct P-wave dominant frequencies for each source …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… polypeptide derived from Leiurus quinquestriatus scorpion venom, has shown selective binding to GBM cells, making it a promising candidate for diagnostic applications and improving tumor visualization. However, the molecular targets of Ctx are unclear, with Matrix Metalloproteinase-2 (MMP-2) and …
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Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
… second measures distances between S4 sites and a scorpion toxin bound to the symmetric axis of the channel just above the pore. These LRET studies argue strongly against the paddle model of voltage sensing, and demonstrate that the physical movements of the S4 segments of Shaker K+ channels are …
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The Design of Complex Weapons Systems in Scorpions: Sexual, Ontogenetic, and Interspecific Variation
<p>Scorpions possess two integrated multifunctional weapons systems. Anteriorly, they maintain a grasping system comprised of a pair of pedipalps ending in chelae that seize and manipulate prey, ward off predators, and secure mates. Posteriorly, they wield a venom delivery system consisting of a …
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