Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Scleraxis"”.
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Scleraxis-mediated regulation of tendon and ligament cell mechanobiology
… remain unclear. The transcription factor scleraxis (Scx) is an interesting candidate for mediating the tendon and ligament mechanoresponse, as it has been shown that Scx expression is induced by cyclic mechanical strain in tenocytes and is required for mechanically-induced stem cell …
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Characterising embryonic stem cell-derived tenocytes and determining the changing role of scleraxis during tendon development
… tendon cells, as well as try to understand if scleraxis (SCX), an essential gene in tendon formation, has different roles at different stages of tendon development. Equine adult, fetal and ESC-derived tenocytes were cultured in a three-dimensional environment, with histological, morphological …
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Complementary Strategies to Promote Mesenchymal Stem Cell Differentiation for Ligament Tissue Engineering
… and over-expression of the transcription factor, scleraxis. First, elastomeric scaffolds were fabricated by electrospinning a segmented poly(esterurethane urea) with variations in fiber diameter and fiber alignment. Primary mesenchymal stem cells and the mesenchymal stem cell line, C3H10T1/2, were …
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Strategies for the Fabrication of Cellularized Micro-Fiber/Hydrogel Composites for Ligament Tissue Engineering
… network and exhibited greater expression of scleraxis, and α-smooth muscle actin compared to the stiffest (31 MPa) fibers. Additionally, preliminary results revealed that the incorporation of fibroblast growth factor-2 and growth and differentiation factor-5 onto micro-fibers through chemical …
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Porcine urinary bladder matrix in an in vitro equine model of tenogenesis
… Decorin, matrix metalloproteinase 13, and scleraxis expression increased significantly over time, but not in response to UBM treatment. Mohawk expression was constant over time. Cartilage oligomeric matrix protein expression decreased over time in both groups. Using a novel ECM hydrogel …
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FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis
… oletettujen kantasolumarkkereiden, GLI1 ja Scleraxis, kanssa. BrdU Pulse Chase -kokeet osoittivat FSP1-syyruston osajoukon säilyttävän merkkiaineen, mikä viittaa FSP1:n leimaavan uuden kanta- ja esisolupopulaation kondyylissä. FSP1:tä ilmentävien solujen tuhoaminen ehdollisen …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
… ligament markers (e.g. collagen type I, decorin, scleraxis, and tenomodulin) on electrospun scaffolds after the application of stretch. However, the cyclic stretch regimen was not able to enhance expression of ECM components. In the third study techniques were developed to produce more clinically …