Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 741 for “"Science General"”.
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Development and Implementation of Theoretical Methods for the Calculation of EPR Parameters in Periodic Simulations
… their CPMD counterparts, as they are the most generally applicable. Through the Gaussian and augmented-plane-wave (GAPW) representation and the aforementioned layered approach, the CP2K methods offer a very attractive accuracy/cost trade-off over the few competing methods applicable to PBC …
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Epistemic extensions of answer set programming
but due to the non-monotonic nature of ASP; the weight can reflect the certainty that the rule itself is correct. ASP programs with incorrect rules may have erroneous conclusions; omitting a correct rule may also lead to errors. To derive the most certain conclusions from an uncertain ASP program; …
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Population-centric warfare: How popular support determines civil war outcomes
In recent years, the most technologically advanced militaries in the world have toiled against guerrilla forces. Counterinsurgent doctrine focuses on a government’s lack of popular support to explain this. Academic literature, however, currently treats popular mobilisation as a dependent variable, …
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Two stages hybrid model of fuzzy linear regression with support vector machines for colorectal cancer
… cancer patients who received treatment in general hospital with twenty five independent variables with different combination of variable types were considered to find the best models to predict the tumor size of CRC. The main objective of this study is to determine the best model to …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… and pE3-E2 cloned into the same plasmid. The general findings of this study were as follows: firstly, comparing the levels of expression of each precursor to its mature form through small-scale protein inductions in E. coli at different temperatures, it was observed that both types of …
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Purine transport in plasmodium falciparum
Purine transport in malaria parasites has become an important potential drug target because the malaria parasite is unable to synthesis purine de novo and has to salvage it from the host milieu through transporter(s). Knowledge of the number, selectivity and kinetic parameters of the transporters …
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Characterisation of quiescin-sulfhydryl oxidase and nematode astacin mutants using functional studies in caenorhabditis elegans.
Nematodes, both free-living and parasitic, are dependant upon their Extra Cellular Matrix (ECM) for multiple aspects of functionality. Two distinct ECMs are present in Caenorhabditis elegans, the basement membrane and the cuticle. The cuticle of C. elegans, like other nematodes is composed largely …
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Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
cAMP is a secondary messenger that is involved in a variety of signalling pathways through its effectors including EPAC, PKA and ion channels. cAMP signalling regulates processes such as memory, muscle contraction and inflammatory responses. PDE enzymes offer a mechanism to negatively regulate …
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Development and application of a novel method to determine large very low density lipoprotein (VLDL1) kinetics
High concentrations of large very low density lipoproteins (VLDL1) give rise to atherogenic dyslipidaemia, which is usually associated with insulin resistant conditions (e.g. obesity) and increases the risk for cardiovascular disease (CVD). Isotopic tracer methods for determining VLDL1 kinetics are …
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Analysis of cyclin dependent kinases in Leishmania
The results obtained from the experiments presented in this study aimed to further explore the role of cyclin dependent kinases and cyclins in the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle …
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An investigation into dystroglycan deficiency in fibroblasts and a role for dystroglycan in cytokinesis
Dystroglycan is a heterodimeric cell adhesion molecule consisting of alpha and beta subunits, which links the actin cytoskeleton to the extracellular matrix. Dystroglycan has an important structural role and is integral for maintaining tissue integrity, but new avenues have research have implicated …
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Kynurenines in neurological disorders
The kynurenine pathway is thought to be involved in neurological disorders but its precise role and the mechanisms involved have yet to be established. Tryptophan can be metabolised via this pathway to produce the neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist, quinolinic acid (QUIN), and …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An …
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Lipoic acid protein ligases in Plasmodium spp.
Protozoan parasites of the genus Plasmodium are the causative agent of malaria. The four human pathogenic species infect more than 500 million people each year, causing the death of at least 1 million people. The most severe form of human malaria is caused by P. falciparum, which is responsible for …
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Modelling sea surface temperature using generalized additive models for location scale and shape by boosting with autocorrelation
… data lead to incomplete information over time. Generalized additive models by boosting with location scale and shape (gamboostLSS) can be applied to overcome this problem. Moreover, they also deal with sparsity, irregular peaks, and autocorrelation in the data. We propose in this thesis extended …
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