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Showing 1 to 20 of 63 for “"Sciatic nerve"”.
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Development of Collateral Circulation in Partially Devascularized Feline Sciatic Nerve
… existing literature in the field of peripheral nerve vascularity has established that nerve function is influenced by vascular supply; however, opinion varies considerably concerning the extent of such dependence. Apparently, influence of vascular supply is unquestioned; its importance is …
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Somatosensory Map Following Stimulation of Rat Sciatic Nerve Using Polyimide Microfabricated Sieve Electrodes
… leading to abandonment of the device. Peripheral nerve interfaces (PNIs) provide an alternative means to interacting with the brain and nervous system at a less invasive level than BCIs. PNIs maintain the benefit of interfacing a discrete neurological maps of sensory function required to make …
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Characterization of Materials Carried by Fast Axoplasmic Transport in Sensory Fibers of the Rat Sciatic Nerve
Made available in DSpace on 2014-12-14T04:27:34Z (GMT). No. of bitstreams: 1 7606737.pdf: 5673432 bytes, checksum: b1b066647f754ac528f98825477918ff (MD5) Previous issue date: 1975
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Characterization of the high frequency alternating current block in the rat sciatic nerve using cuff electrodes and macro-sieve electrodes
… fabricated and non-chronically implanted in the sciatic nerve of two-month-old Lewis rats. A proximal constant current stimulus to the nerve was blocked by applying a high frequency sinusoidal signal to the distally placed tripolar cuff electrode. The frequency voltage characteristic of the …
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Effects of electrical stimulation and testosterone on regeneration-associated gene expression and functional recovery in a rat model of sciatic nerve crush injury
… is often suboptimal following peripheral nerve injury (PNI). Research to date indicates that the greatest success in achieving full functional recovery will require the use of a combinatorial approach that can simultaneously target different aspects of the post-injury response. In general, …
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The impact of primary motor cortex, spinal cord, and sciatic nerve cooling on spinal reflex activity in the rat: a reversible deactivation study
… the primary motor cortex, spinal cord, and sciatic nerve, are incompletely known. This study aims to consider each of these to develop a better understanding of how spinal cord reflexes and the relationship between the central and peripheral nervous systems, particularly in terms of motor …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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The vascular variability of the iliac system and clinical diagnosis in radiology and neurology
The sciatic nerve is the largest nerve in the human body giving both<br/>motor and sensory innervations to the lower limb. It can be affected in chronic<br/>diseases, such as diabetes, or compressed anatomically by structures such as<br/>piriformis and aneurysms leading to sciatica or paralysis of …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG …
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Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
… neuromuscular function in both muscle and the sciatic nerve, and exercise adaptations (mitochondrial respiration and RNA sequencing) before overt cognitive impairment. We found that 5xFAD mice develop neuromuscular dysfunction as early as 4 months of age, characterized by impaired nerve- …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional recovery following a critical nerve defect. Evaluation of …
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Neuroprotective Potential of a Lanosteryl Triterpene from Protorhus longifolia Stem Bark (Benrh.) Engl in high fat diet fed and STZ -induced diabetic neuropathy in rats
… pathways alters the antioxidant defense of nerve cells and cause protein malfunction, resulting in loss of neurotrophic support. Currently, there is no specific treatment for neuropathy and the current antidiabetic drugs fail to prevent development of long-term diabetic complications. …
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Retinoic acid signalling after peripheral nerve injury
Although the problem of nerve regeneration has been studied since the beginning of the 20th century, the molecular mechanisms of this process are still largely unknown. Recently, the involvement of retinoic acid (RA) signalling was also proposed to regulate PNS regeneration based on its regulation …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… groups underwent a gastrocnemius harvest or a sciatic nerve ligation protocol prior to sacrifice. In combination with MitoTracker™ injections, we used immunohistochemical labeling to target the mitochondrial translocase of outer membrane, TOM20. We used immunolabeling to further delineate …
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Repeatable and adjustable on-demand local anesthesia using externally-triggerable liposomes
… triggerable liposomes that provide on-demand nerve block at the desired timing, intensity and duration. The responsiveness of the liposomes towards the external triggering was studied in vitro, where the light triggerable system showed 5.6% drug release upon irradiation with 730 nm light and …
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Implementation of Novel Group Delay Decomposition Method and Surgical Protocol for Assessing Peripheral Neuropathy
… procedure for exposing and stimulating the sciatic nerve of an anesthetized rodent for purposes of obtaining conduction velocity readings. The ability to accurately quantify nerve conduction velocity has potential for use in the field of diagnostic medicine and disease characterization. An …
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Electrochemical Modulation of Peripheral Nerves Using Ion-Selective Electrodes
… a rapid-manufacturing process for fabricating nerve cuff electrodes compatible with ISM coating and tested it in vivo, and (4) built off this foundational work to fabricate a Ca²⁺-selective nerve cuff electrode suitable for electrochemical operations, implanted in vivo on the sciatic nerve of a …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… Using CXB-NE in rats that have peripheral nerve injury constricting the sciatic nerve relieves hypersensitivity, a pain-like behavior. The treatment also decreases inflammation associated with this chronic constriction injury (Janjic et al, 2018; Saleem et al, 2019b; Stevens et al, 2019). …
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Effects of Electrical Stimulation and Testosterone in Translational Models of Peripheral Nerve Injury
<p>As functional recovery following peripheral nerve injury is dependent upon successful regeneration and target reconnection, combinatorial treatments that enhance different regeneration events may be required for recovery from severe injuries. The neurotherapeutic effects of electrical …
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