Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Schwannomas"”.
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and their relevant signalling pathways. At present the only treatment options for NF2 are surgery or …
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
Although schwannomas and meningiomas are generally benign and slow-growing, the mass effect of either tumour within the nervous system causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment …
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STUDY OF PHYSIO-PATHOLOGICAL MECHANISMS AT THE BASE OF SCHWANNOMA DEVELOPMENT
Schwannomas are the most common type of peripheral nerve tumor. Usually, schwannomas are benign, well‐circumscribed tumors clinging to peripheral nerves, consisting of a clonal population of Schwann cells (SCs), which often undergo cystic and degenerative changes. Most cases are sporadic, however, …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… schwannoma and meningioma. A large group of schwannomas and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic mechanisms leading to the occurrence of schwannomas and …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… has been found in sporadically occurring schwannomas and meningiomas, as well as in mesothelioma. Merlin has two major isoforms that differ in only one exon at the C-terminal. Previous work hypothesized that isoform 11 is unable to suppress growth. In this thesis, I show that both of the …
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Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma
… in dorsal root and vestibular ganglia schwannomas in the NF2fl/fl Periostin-CRE mouse schwannoma model, and in meningioma murine orthotopic xenograft tumours.<br/><br/>In summary, this project has revealed a significant role for ALDH enzymes, particularly ALDH1A3, in driving tumour …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… Type 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available treatments for this group of tumours are surgery and radiosurgery/radiotherapy. Hence, there is an urgent need for new …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
Vestibular schwannomas (VSs), the most common tumors of the cerebellopontine angle, arise from Schwann cells of the vestibular nerve. VSs can lead to sensorineural hearing loss (SNHL), disequilibrium, facial nerve paralysis, and brainstem compression. Treatment options available today are …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully effective and there is an urgent need for new therapeutic options. Human endogenous retroviruses (HERVs) are retroviruses …