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Showing 1 to 20 of 71 for “"Schwann Cells"”.
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Response of stretch-injured schwann cells
… white matter axonal tracts, oligodendrocytes. Schwann cells can help take a first look into stretch injured glia cells from the Peripheral nervous system. In order to observe changes in Schwann Cells a stretch injury device is used to produce the effects of severe and moderate injuries. Schwann …
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Glucose-Induced Apoptosis of Schwann Cells In vitro
The loss of Schwann cells in the peripheral nerves is thought to be responsible for the pathologies associated with diabetic neuropathy. As diabetes causes increased extracellular glucose levels, glycosylation or non-enzymatic glycation of cell surface receptors may interfere with normal signaling …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… by palmitic acid lipotoxicity (PA-LTx) in Schwann cells cultured in euglycemic and hyperglycemic conditions. The data show that immortalized Schwann cell (iSC), as well as primary Schwann cell (pSC) cultures exposed to elevated levels of PA induced an apoptotic cell death that is dose and …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… However, in response to demyelination, Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought to have migrated into the CNS from peripheral sources, lineage tracing studies …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
Vestibular schwannoma (VS) is a benign peripheral nerve tumour arising from Schwann cells (SCs) of the vestibulocochlear nerve (VN) and represents the most common tumour of the cerebellopontine angle. Although the loss of NF2/merlin is a well-established driver of schwannoma (SCH) formation, likely …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
… suggested a non-cell autonomous contribution of Schwann cell defects to MN degeneration. Supporting this, I found that restoration of Smn in Schwann cell precursors (SCPs) of smn morphants partially ameliorates MN defects. Transcriptome analysis of Smn deficient SCPs to unravel potential non-cell …
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Cellular Interactions During Motor Nerve Regeneration
… The interactions between injured nerves with cells in their environment, as well as the functional significance of these interactions, have not been determined in vivo and in real time. Here we provide the first minute-by-minute account of cellular interactions between laser transected motor …
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Role of Laminins in the Development of the Peripheral Nervous System
… laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminins fail to differentiate to myelinating and non-myelinating Schwann cells …
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Versuche zur Rekonstruktion erektiler Nerven über Silikonröhrchen in Kombination mit gezüchteten homologen Schwannschen Zellen bei der Ratte
… nerves within silicone tubes seeded with Schwann cells in rats. Resection of the cavernosal nerves is often necessary during radical prostatectomy and causes erectile dysfunction. Autologous nerve transplantats seemed to be the treatment of choice in the past. Further detailed knowledge of …
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An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… a consequence of Mycobacterium leprae infection. Schwann cells, the neural target of M. leprae, have a central role in leprosy histopathology including axonotrophy, altered myelin architecture and demyelination. The mechanisms of nerve damage have not been fully elucidated but appear to be the …
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
… in rat dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in cocultures. Its expression level increased during active myelin synthesis in contrast to …
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Cellular organisation of peripheral nerve and the neuromuscular junction
The organisation of cells in the peripheral nervous system is crucial for its proper function. Action potential generation, conduction and synaptic transmission to the muscle fibres are dependent not only on cells directly implicated in these functions (i.e. neurons and muscle fibers) but also on …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and toll/interleukin 1 receptor motif containing protein 1 (SARM1). …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines from macrophages and Schwann cells needs to be tightly regulated to ensure efficient regeneration and to prevent chronic inflammation. Currently …
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
Olfactory ensheathing cells (OECs), the glia of the olfactory nerve, are promising candidates for patient-specific cell-mediated repair of both peripheral nerves and the spinal cord. The recent discovery that OECs originate from the neural crest, rather than the olfactory epithelium as previously …
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The control of Schwann cell myelination during development and after nerve injury
Schwann cells are the principal glial cell of the peripheral nervous system and are responsible for axon maintenance, regeneration and increasing saltatory conduction of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling …
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Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
… disease Leprosy. In humans, M. leprae infects Schwann cells, a type of glial cell that surrounds neurons and is responsible for the formation of the myelin sheath that encases the axon. To aid in nerve regeneration post-injury, Schwann cells have an innate plasticity ability that allows them to …
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Immuno-histochemical method for demonstration of Lactic Dehydrogenase "M" subunits in Rat Skeletal Muscle, Kidney and Peripheral Nerve
… procedure and in peripheral nerve both the Schwann cells and axons stain. The nuclei of muscle fibers. kidney tubular cells and Schwann cells are clearly stained using the immuno-peroxidase procedure, whereas they do not stain with the conventional tetrazolium method for LDH.</p>
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