Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Schwann Cell"”.
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… nerve disease is well appreciated, whether Schwann cell: SC) mitochondrial deficits contribute to peripheral neuropathies is unclear. Greater insight into the biology and pathology of SC mitochondrial metabolism could be relevant to the treatment of peripheral neuropathies, particularly …
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Taurine depletion and Schwann cell dysfunction in diabetic neuropathy
… taurine supplementation are not well understood. Schwann cells are highly vulnerable to hyperglycaemia-induced stress which plays a key role in the pathogenesis of diabetic neuropathy, however, the mechanisms behind these effects are not well understood. In these studies I have elucidated the …
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The control of Schwann cell myelination during development and after nerve injury
Schwann cells are the principal glial cell of the peripheral nervous system and are responsible for axon maintenance, regeneration and increasing saltatory conduction of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling …
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Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
… leprae is a strictly obligate, intracellular bacterium that is a causative agent of the chronic infectious disease Leprosy. In humans, M. leprae infects Schwann cells, a type of glial cell that surrounds neurons and is responsible for the formation of the myelin sheath that encases …
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An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… a consequence of Mycobacterium leprae infection. Schwann cells, the neural target of M. leprae, have a central role in leprosy histopathology including axonotrophy, altered myelin architecture and demyelination. The mechanisms of nerve damage have not been fully elucidated but appear to be the …
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Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
… their role as regulators of neuronal survival. Schwann cells are the major glial elements in the peripheral nervous system and, therefore, could play a major functional role in supporting neuronal differentiation and survival in nervous system. Here, we have characterized a neurotrophic factor …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and toll/interleukin 1 receptor motif containing protein 1 (SARM1). …
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
… expression of synaptic myonuclei and terminal Schwann cells and the development of a highly-regulated synaptic structure. To understand neuromuscular junction abnormalities associated with cerebral palsy, a method for assessing the regulation of gene expression in synapse-associated nuclei is …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… signal transduction pathways between neurons and Schwann cells that regulate the steps in myelin formation. Schwann cell/neuronal co-cultures were used to study myelin synthesis in the peripheral nervous system. Progesterone and glucocorticoids were found to increase the rate of myelin synthesis …
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Role of Laminins in the Development of the Peripheral Nervous System
… laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminins fail to differentiate to myelinating and non-myelinating Schwann cells …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… successful communication between axons and glial cells including Schwann cells in peripheral nervous system and oligodendrocytes in central nervous system, is required for the proper functions of both neurons and glia. Three types of alternatively-spliced proteins belonging to the neuregulin1 …
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A Synthetic Lethal shRNA Screen and Genetic Proof of Concept Identifies RAC1 as a Novel Target to Disrupt Plexiform Neurofibroma Formation
… is the presence of complex multilineage Schwann cell-derived plexiform neurofibromas (PN). Historically, little clinical success has been achieved targeting PN through surgery or chemotherapies. I performed an shRNA library screen of patient-derived Schwann cell lines to identify novel …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I sought to …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
… Studies in SMA animal models suggested a non-cell autonomous contribution of Schwann cell defects to MN degeneration. Supporting this, I found that restoration of Smn in Schwann cell precursors (SCPs) of smn morphants partially ameliorates MN defects. Transcriptome analysis of Smn deficient …
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Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
… transcriptomics and methylome analyses. Through cell line and mouse models, we confirmed these subsets are defined by enrichment of SHH and Wnt pathways. These pathways can also be therapeutically targeted with small-molecule inhibitors. The second objective focused on the role of PRC2 in gene …
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Fluorescence characterization of protein and lipid dynamics
… characterize the formation of myelin in neuron Schwann cell co-cultures. Domain motion upon substrate binding was examined in adenylate kinase using fluorescence resonance energy transfer. The process of myelin formation was examined by observing the growth and composition of myelin using a …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… in this regenerative process are macrophages, Schwann cells and the production of inflammatory cytokines. The production of inflammatory cytokines from macrophages and Schwann cells needs to be tightly regulated to ensure efficient regeneration and to prevent chronic inflammation. Currently …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… to lipid overload that has been associated with cellular dysfunction leading to cellular death. The mechanism of lipotoxicity and its impact on the nervous system is critical as it can lead to debilitating neurological conditions. This study examines key cellular events induced by palmitic acid …
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
Olfactory ensheathing cells (OECs), the glia of the olfactory nerve, are promising candidates for patient-specific cell-mediated repair of both peripheral nerves and the spinal cord. The recent discovery that OECs originate from the neural crest, rather than the olfactory epithelium as previously …
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