Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Schwann"”.
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The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
… nerve disease is well appreciated, whether Schwann cell: SC) mitochondrial deficits contribute to peripheral neuropathies is unclear. Greater insight into the biology and pathology of SC mitochondrial metabolism could be relevant to the treatment of peripheral neuropathies, particularly …
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Response of stretch-injured schwann cells
… white matter axonal tracts, oligodendrocytes. Schwann cells can help take a first look into stretch injured glia cells from the Peripheral nervous system. In order to observe changes in Schwann Cells a stretch injury device is used to produce the effects of severe and moderate injuries. Schwann …
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Glucose-Induced Apoptosis of Schwann Cells In vitro
The loss of Schwann cells in the peripheral nerves is thought to be responsible for the pathologies associated with diabetic neuropathy. As diabetes causes increased extracellular glucose levels, glycosylation or non-enzymatic glycation of cell surface receptors may interfere with normal signaling …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… by palmitic acid lipotoxicity (PA-LTx) in Schwann cells cultured in euglycemic and hyperglycemic conditions. The data show that immortalized Schwann cell (iSC), as well as primary Schwann cell (pSC) cultures exposed to elevated levels of PA induced an apoptotic cell death that is dose and …
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Taurine depletion and Schwann cell dysfunction in diabetic neuropathy
… taurine supplementation are not well understood. Schwann cells are highly vulnerable to hyperglycaemia-induced stress which plays a key role in the pathogenesis of diabetic neuropathy, however, the mechanisms behind these effects are not well understood. In these studies I have elucidated the …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… However, in response to demyelination, Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought to have migrated into the CNS from peripheral sources, lineage tracing studies …
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The control of Schwann cell myelination during development and after nerve injury
Schwann cells are the principal glial cell of the peripheral nervous system and are responsible for axon maintenance, regeneration and increasing saltatory conduction of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
Vestibular schwannoma (VS) is a benign peripheral nerve tumour arising from Schwann cells (SCs) of the vestibulocochlear nerve (VN) and represents the most common tumour of the cerebellopontine angle. Although the loss of NF2/merlin is a well-established driver of schwannoma (SCH) formation, likely …
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Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
… disease Leprosy. In humans, M. leprae infects Schwann cells, a type of glial cell that surrounds neurons and is responsible for the formation of the myelin sheath that encases the axon. To aid in nerve regeneration post-injury, Schwann cells have an innate plasticity ability that allows them to …
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An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… a consequence of Mycobacterium leprae infection. Schwann cells, the neural target of M. leprae, have a central role in leprosy histopathology including axonotrophy, altered myelin architecture and demyelination. The mechanisms of nerve damage have not been fully elucidated but appear to be the …
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Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
… their role as regulators of neuronal survival. Schwann cells are the major glial elements in the peripheral nervous system and, therefore, could play a major functional role in supporting neuronal differentiation and survival in nervous system. Here, we have characterized a neurotrophic factor …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and toll/interleukin 1 receptor motif containing protein 1 (SARM1). …
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
… expression of synaptic myonuclei and terminal Schwann cells and the development of a highly-regulated synaptic structure. To understand neuromuscular junction abnormalities associated with cerebral palsy, a method for assessing the regulation of gene expression in synapse-associated nuclei is …
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Tissue Engineering bei peripheren Nerven : dreidimensionale Fibrin/Schwann-Zellen-Matrix in Poly-Caprolacton-Konduiten zur geführten Defektüberbrückung
… (PCL)-Nervenleitschienen bei Applikation von Schwann-Zellen, einer Fibrin-Matrix und des neurotrophen Faktors LIF (Leukemia Inhibitory Factor). Hierzu wurden Schwann-Zellen aus dem N. ischiadicus neonataler Ratten kultiviert. Als Läsionsmodell diente ein 10mm langer Defekt im bukkalen Ast des …
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Assessing Value in Upstream Health Interventions: A Case Study of the Dr. Paul Schwann Centre Cardiac Rehabilitation Program
… Regina Qu’Appelle Health Region – the Dr. Paul Schwann Centre Cardiac Rehabilitation Program. This research investigates the policy problem of assessing value in upstream interventions through a case study of this upstream health intervention. Through a three-pronged analysis of program-level …
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Role of Laminins in the Development of the Peripheral Nervous System
… laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminins fail to differentiate to myelinating and non-myelinating Schwann cells …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… signal transduction pathways between neurons and Schwann cells that regulate the steps in myelin formation. Schwann cell/neuronal co-cultures were used to study myelin synthesis in the peripheral nervous system. Progesterone and glucocorticoids were found to increase the rate of myelin synthesis …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… between axons and glial cells including Schwann cells in peripheral nervous system and oligodendrocytes in central nervous system, is required for the proper functions of both neurons and glia. Three types of alternatively-spliced proteins belonging to the neuregulin1 (NRG1) gene family …
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