Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Schistosome"”.
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A zebrafish model to study the schistosome egg granuloma
… zebrafish model to study the formation of the schistosome egg granuloma in detail within an optically transparent animal. I have developed the tools and techniques for implantation of individual Schistosoma mansoni eggs into zebrafish, followed by intravital microscopy to observe the formation …
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Exploring the interactions between schistosome eggs and the human host
… per year in Sub-Saharan Africa alone. Three schistosome species are mainly responsible for human infection; Schistosoma mansoni, S. japonicum and S. haematobium. Schistosomiasis progresses through several stages, culminating with the establishment of a chronic infection. This chronic stage of …
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Social and environmental epidemiology of schistosomiasis in Ghana
… context in which the transmission of schistosome infections occurs may render this global approach of chemotherapy implementation inefficient. Evidence from different endemic settings points to the fact that the transmission dynamics of schistosome infections is not merely an interplay …
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Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni
Schistosomes are parasitic flatworms that infect over 200 million people, primarily in poverty-stricken developing countries, causing extensive morbidity and mortality. Schistosomes have a great deal in common with other parasitic flatworms such as liver flukes and tapeworms. Namely, they are …
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STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… a disease caused by parasitic flatworms called schistosomes, affects 240 million people in developing regions, including large parts of Africa, Asia, and South America. In some of these areas, the disease affects over 50% of the population, making Schistosomiasis second only to Malaria in …
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
Schistosomes are parasites causing one of most prevalent and serious neglected tropical diseases. Their immense egg output in the host is the main source of pathology, placing their reproductive biology of great importance for scientific researches. A bizarre, and physiologically meaningful …
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Identification and structural bioinformatics of druggable proteins in schistosoma species
… of new drug since studies have shown that schistosomes are becoming resistant to the widely accepted first-line drug-of-choice Praziquantel (PZQ). Therefore, the present study describes the exploration of broad-spectrum therapeutic potentials of Antimicrobial peptides (AMPs) in the design …
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Concurrent Infection of TRYPANOSOMA MUSCULI Kendell, 1906, and SCHISTOSOMA MANSONI Sambon, 1907 in Mice
… to affect those of the blood fluke. Effects of schistosome membrane function must also be ruled out as no reduction in worm burden and no morphological abnormalities were observed. Both immune and normal rat serum caused an increase in the number of worms recovered. This is most probably due to …
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Transcriptome characterisation of the intra-mammalian stage of male and female Schistosoma mansoni
… 3.3 million lost disability-adjusted life years. Schistosomes are dioecious and male and female worms find one another and pair in the blood vessels of the host’s liver. This sets in motion a unique feature of schistosome biology, the pairing-dependent sexual maturation of the female worms. Over …
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The role of IL-4Ra during acute schistosomiasis
… infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.
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Molecular cloning, recombinant protein expression and structural characterization of a universal stress G4LZI3 protein from Schistosoma mansoni
… by the larvae of a blood fluke parasite called schistosome. Different species of schistosomes are responsible for various types of schistosomiasis but most of the burden of the disease is attributed to the species Schistosoma mansoni. The outcome of S. mansoni infection includes damage to vital …
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Structural Determination of the novel Universal Stress Protein G4LZI3 from Shistosoma mansoni using X-ray Crystallography
… Africa alone where more than 90% of all schistosome infections stem from. Treatment for the disease has now become an issue of gross concern worldwide without the development of a vaccine as well as growing evidence of drug resistant strains against Praziquantel, which has been the …
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Human antibody-mediated immunity against infection and parasite fecundity in Schistosoma mansoni and Schistosoma haematobium infection
… against infection and reduce fecundity in human schistosome infections. The relative contribution of exposure to infection and IgE antibody responses against schistosomes were explored using a mathematical modelling approach. Age intensity and serology profiles of sub-cohorts were reproduced to …
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Concurrent Infections of SCHISTOSOMA MANSONI and TRYPANOSOMA EQUIPERDUM in Mice
… trypanosomes after the 5th, 7th, and 9th week of schistosome infection die significantly earlier than controls. It is suggested that a synergistic effect is produced in the mixed infection of <em>S. mansoni</em> and <em>T. equiperdum</em>.</p> <p>The correlation between the hours of survival and …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
… a diverse range of organisms not susceptible to schistosome infection, including turtles, fish and other molluscs. I demonstrate the substantial contribution of repetitive elements to S. mansoni genes, including evidence of a potential instance of exaptation. Finally, I leveraged the repeat …
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Comparative and population genomic analyses of the parasitic blood flukes
… parasitic trematodes of the genus Schistosoma. Schistosomes are considered a considerable public health concern responsible for infecting over 236 million people across 78 endemic nations. It is especially common among children in low and middle-income countries, with 90% of infections occurring …
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Biophysical characterisation of the interaction between the S.mansoni G4LZI3 protein and the NAD binding domain of glyceraldehyde-3 phosphate dehydrogenase
… regarding the emergence of PZQ-resistant schistosome species. The design and development of an alternative drug and/or vaccine against the disease has become an urgent requirement. Hence this study aimed to explore an interaction between two Schistosoma mansoni proteins, G4LZI3 and the NAD …
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Engagement of human host receptors by the antiparasitic drug praziquantel
… (R)-PZQ causes a rapid paralysis of adult schistosome worms and damages the worm tegument. However, the mechanism of action of PZQ is unknown. Thus, identifying relevant molecular targets of PZQ is necessary to aid the development of new antiparasitic therapies and provide treatment …
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Ritmos biológicos na emergência de Cercárias de Shistosoma mansoni Sambon, 1907 (Platyhelminthes: Digenea) em infecções mono e plurimiracidianas de Biomphalaria glabrata (Say, 1818) (Mollusca: Gastropoda)
… with one and five miracidia of sympatric schistosome were kept at outdoor conditions. Other observations included the estimations of the infection rate, the pre-cercarial period,the survival of infected snails, and the number of emerged cercariae at each 24-h intervals.The correlation …
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Characterization of germ cell development in free-living and parasitic flatworms
… genes functioning in different stages of schistosome male gametogenesis, as well as genes necessary for egg production in the mammalian host. Together, our studies uncover novel roles for numerous genes critical for germ cell development in free-living and parasitic flatworms.
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