Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Schistosoma"”.
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Human antibody-mediated immunity against infection and parasite fecundity in Schistosoma mansoni and Schistosoma haematobium infection
Through a combination of epidemiological and proteomic methods, the aim of this thesis was to advance understanding of antibody-driven immune responses that partially protect against infection and reduce fecundity in human schistosome infections. The relative contribution of exposure to infection …
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Carbon Dioxide Fixation in Schistosoma Mansoni
<p>Adults of the blood fluke <em>Schistosoma mansoni</em> were perfused from the hepatic portal system of CF1 female mice sixty to seventy days post infection. The worms were then incubated in Eagle’s minimal essential medium with glutamate and 0.03 mg/100 ml of nonlabelled aspartic acid. To this …
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The penetration protease of the cercariae of Schistosoma mansoni
… of the proteases released by the cercariae of Schistosoma mansoni while penetrating mammalian skin. The proteases present in secretions collected from the preacetabular glands of cercariae were shown to be active against ¹²⁵I-labelled fibrin but not against undenatured ³H-collagen. A sensitive …
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Identification and structural bioinformatics of druggable proteins in schistosoma species
… (AMPs) in the design of alternative anti-schistosomal treatment regimen. AMPs are natural antibiotics produced by all living species; they have multifunctional properties and are currently explored as a vital source for the development of new drugs. The use of therapeutic peptides in …
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Concurrent Infections of SCHISTOSOMA MANSONI and TRYPANOSOMA EQUIPERDUM in Mice
… <em>T. equiperdum</em> on mice infected with <em>Schistosoma mansoni</em>.</p> <p>In order to maintain experimentally obtained standard hours of survival (88 hrs) in mice inoculated intraperitoneally with 150,000 <em>T. equiperdum</em>, it was found that trypanosomes removed from the donor rat …
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Avaliação da atividade anti-Schistosoma mansoni de novos ftalimido-tiazóis
… que atuem na forma adulta e forma larval do Schistosoma mansoni é necessária e urgente. Com o objetivo de identificar novos compostos protótipos que possuam atividade esquistossomicida, a atividade anti- S. mansoni de 9 compostos heterocíclicos classificados como ftalimido-tiazol foi testada …
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Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni
Schistosomes are parasitic flatworms that infect over 200 million people, primarily in poverty-stricken developing countries, causing extensive morbidity and mortality. Schistosomes have a great deal in common with other parasitic flatworms such as liver flukes and tapeworms. Namely, they are …
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Theoretical modelling of temperature and rainfall inuence on Schistosoma species population dynamics
… on the schistosomes. The reoccurrence of Schistosoma infections over the years may result into cancer of the bladder, obstruction in urinary tract, portal or pulmonary hypertension and even death. This study was de- veloped to investigate the in uence of temperature and rainfall on …
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
… of the enzyme by GLI1. Virgin female Schistosoma mansoni can sexually develop and eventually lay eggs by being soaked in BATT supplemented media. This result is pioneering in understanding the schistosome female-male interplay and provides novel therapeutic targets directly related to …
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Some Aspects of Carbohydrate Metabolism in the Cercariae of SCHISTOSOMA MANSONI Sambon, 1907
<p>Cercariac of <em>Schistosoma mansoni</em> were studied for glycogen utilization, uptake of glucose from solution, lactic acid production, and respiration.</p> <p>Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined …
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Transcriptome characterisation of the intra-mammalian stage of male and female Schistosoma mansoni
Schistosoma mansoni is a member of a genus of platyhelminths whose members cause the disease schistosomiasis. Particularly prevalent in sub-Saharan Africa, it is thought to be directly responsible for approximately 5500 deaths per year, as well as contributing significantly to morbidity, being …
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Concurrent Infection of TRYPANOSOMA MUSCULI Kendell, 1906, and SCHISTOSOMA MANSONI Sambon, 1907 in Mice
<p>The possible effects of ablastin on <em>Schistosoma mansoni</em> were investigated by (1) establishing a concurrent infection of <em>Trypanosoma musculi</em> and <em>Schistosoma mansoni</em> in mice, and (2) by obtaining <em>Trypanosoma lewisi</em> immune rat serum (ablastin) and injecting it …
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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to …
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Prevalence and factors associated with Schistosoma Haematobium infection among School going Children of Katete District
… of Schistosomiasis Results: The prevalence of Schistosoma haematobium was 21.7% (104/480); 95% confidence interval (CI) = 18.0 – 25.4). Among the 8 schools, Soloboni had the highest prevalence of 86.7% while Hetty Denin had the lowest with 1.7%. Girls had a higher prevalence of 22.4% compared …
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Patterns of Gene Expression in Schistosoma mansoni larvae associated with Infection of the Mammalian Host
Larval schistosomes infect the human host by penetration of unbroken skin, before gaining access to a blood vessel and beginning their intravascular life. The work in this thesis focuses on the mammalian infection process, as it would be the ideal point to interrupt the life cycle. A whole organism …
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Avaliação da atividade do complexo de inclusão da βlapachona em ciclodextrina frente ao Schistosoma mansoni
… 78 países e territórios estejam infectadas pelo schistosoma em todo o mundo. O surgimento de cepas resistentes ou tolerantes ao praziquantel (PZQ), bem como a sugestiva atuação esquistossomicida da β-lap, nos impeliram a avaliar a atuação in vivo desta naftoquinona complexada em …
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Mobile genetic element contribution to the genome architecture of the human parasitic flatworm Schistosoma mansoni
… Schistosomiasis is caused by trematodes of the Schistosoma genus, with Schistosoma mansoni being the best characterised species and responsible for a significant proportion of deaths. S. mansoni has a complex life cycle involving two free living aquatic stages, a definitive human host and …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
… regions. Recently, the socio-economic impact of Schistosoma infections have been reported to surpass that of malaria in sub-Saharan Africa, as schistosomiasis is known to cause severe damage to various organs thereby impairing childhood development and adult productivity. Schistosoma mansoni one …
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STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… we performed a large-scale RNAi screen in adult Schistosoma mansoni, and discovered 3 genes that produce an identical type of sickness in the worm. Disruption of the genes thousand-and-one kinase (TAO), serine threonine kinase 25 (STK25), or cerebral cavernous malformations 3 (CCM3) by RNAi in …
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