Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1022 for “"Scaffolds"”.
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Designing Scaffolds for Directed Cell Response in Tissue Engineering Scaffolds Fabricated by Vat Photopolymerization
… VP an attractive option for the fabrication of scaffolds for tissue engineering. However, there are few printable materials with low cytotoxicity that encourage cellular adhesion. In addition, these resins are not readily available and must be synthesized. A novel resin based on …
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Engineering developable miniprotein ligand scaffolds
… sequence-function fitness landscape. Protein scaffolds, characterized by a conserved framework to support an engineered variable active site, have proven effective in navigating this landscape. While monoclonal antibodies are established natural scaffolds, miniproteins offer advantages over …
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DNA scaffolds for functional hydrogels
DNA scaffolds self-assembled by short-stranded synthetic DNA can be tailored to build thermally reversible hydrogels with target binding sites. These hydrogels exhibit highly selective binding properties due to the specificity of DNA and also provide an aqueous environment for various reactions to …
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New scaffolds for molecular recognition
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Biosynthesis of tetrahydroisoquinoline scaffolds in yeast
… and novel phenylpropylisoquinoline scaffolds. By feeding engineered yeast nonstandard amino acids, which can be metabolized by the yeast Ehrlich pathway, scaffolds for tetrahydroisoquinoline alkaloids were detected and their relative abundance quantified using mass spectrometry. …
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Modulating Neuroinflammation with Porous Templated Scaffolds
Neuroelectronic interfaces can restore mobility and independence for patients with neurological conditions such as spinal cord injury, stroke, or limb loss. However, unstable neural recording performance remains unresolved. Via the foreign body reaction, macrophages and glial cells develop a “glial …
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Mandibular reconstruction: platelet rich plasma & scaffolds.
Contains fulltext : 19540_mandire.pdf (Publisher’s version ) (Open Access)
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Investigation of bioactive scaffolds as antimicrobials
… acid derivatives identified the necessary scaffolds to elicit anti-MRSA, antifungal, and potentiating activity for this compound class. During an antimicrobial screening program of Copp-group compounds from previous projects, 1,5-disubstituted imidazoles and ascididemin scaffolds were …
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Viscoelastic characterization of collagen-GAG scaffolds
… to determine whether or not collagen-GAG scaffolds exhibit linear viscoelastic behavior. Tension tests were performed on dry and hydrated engineered collagen-GAG scaffolds in order to develop a stress-strain curve. Strains that fell in the linear elastic region of these curves were …
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Biomechanical properties of engineered collagen scaffolds
… of crosslinking on the stiffness of collagen scaffolds. Engineered non-crosslinked and dehydrothermally crosslinked chondroitin-6-sulfate collagen scaffolds were hydrated and loaded in tension, and their mechanical properties were compared. It was found that non-crosslinked scaffolds …
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Topographically and Mechanically Tunable PNIPAM Scaffolds
… substrates coated with PNIPAM films. The scaffolds are investigated for structural and me- chanical responses to thermally driven changes in the PNIPAM hydration states using atomic force microscopy (AFM). AFM measurements on our lithographically patterned substrates show that the …
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Research towards novel immunotherapeutic vectors: calixarene scaffolds
The aim of this project was to generate a new type of therapeutic delivery system and immunogenic vector, based on calixarenes, that is able to not only deliver immunogenic peptide but also act as a potential cancer vaccine. The introduction presents calixarenes derivatives in the context of …
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Precursor-Directed Identification of Natural Product Scaffolds
The rapid generation of natural product analogs is a fundamental challenge in both the optimization of medicinal potency and exploration of novel biological activity. Previous work with Streptomyces variabilis has demonstrated that natural products that incorporate non-enzymatic transformation can …
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Trabecular Calcium Phosphate Scaffolds for Bone Regeneration
… and characterize calcium phosphate ceramic scaffolds matched to the local architecture of natural trabecular bone and to apply tissue engineering strategies for the study of cell behavior in both in vitro and in vivo models.The specific role of environment on cell stress pathways was …
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Developing scaffolds for full-thickness esophageal replacement
L'abstract è presente nell'allegato / the abstract is in the attachment
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Chitosan fibrous scaffolds for cartilage tissue engineering
… and chemical characteristics of chitosan scaffolds may be improved for cartilage engineering application. We planned to evaluate chitosan meshes produced by a novel technique and the effect of chitosan structure on mesenchymal stem cells (MSCs) chondrogenesis. Another objective was to …
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Drug eluting electrospun scaffolds for tissue regeneration
The desired healing response to electrospun scaffolds in tissue engineering is often limited by poor ingrowth due to insufficient porosity, thrombogenicity, lack of vascularisation and/or excessive inflammation. This study aimed at increasing structural porosity and incorporating/delivering …
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