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Showing 1 to 20 of 21 for “"Scaffold Proteins"”.
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Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Design principles of mammalian signaling networks : emergent properties at modular and global scales
… Areas of interest have emphasized the role of scaffold proteins in protein kinase cascades, modeling relevant biophysical processes related to T cell activation, design principles of signal transduction focusing on multisite phosphorylation, quantifying the notion of signal duration and the …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… of synapses are mediated by large suites of proteins. In most cases, many of these proteins are tethered together by synaptic scaffold proteins. Scaffold proteins have a large number and typically a variety of protein interaction domains that allow many different proteins to be assembled into …
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Engineering a Reverse C4 Photosynthetic Pathway in C3 species Arabidopsis thaliana
… enzymes of a metabolic pathway via protein scaffold was tested. Three enzymes for the biosynthesis of betalain were transiently expressed in tobacco in the presence of scaffold proteins of various structures. However, betalain production was inhibited. Varying the number of domains on …
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Mathematical Modeling and Computational Studies for Cell Signaling
… a mate is sufficiently close. In many cases, scaffold proteins are thought to play a key role during this process. The molecular mechanisms that control the bistability decision is not yet fully understood. Here we show that bistability mechanism can arise from multisite phosphorylation system …
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Models and analysis of yeast mating response : tools for model building, from documentation to time-dependent stimulation
… carefully measured abundances of mating system proteins, I analyzed a model of the mating system mitogen activated protein kinase cascade. I found that varying the abundance of the scaffold protein Ste5, but not the abundances of other proteins, is expected to result in a quantitative tradeoff …
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Molecular Details Of The Mitochondrial Iron Sulfur Cluster Assembly Pathway
… frataxin's interaction with the partner proteins during the iron sulfur cluster assembly pathway. This will provide us important information regarding modulation of metal delivery by frataxin and how it interacts with partner proteins, which can be used for treatment of several iron …
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Structure and Composition of Postsynaptic Densities
… The PSD, which is composed of signaling, scaffold and cytoskeletal proteins, supports and organizes neurotransmitter receptors within the synaptic membrane in addition to bridging signaling with the actin cytoskeletal network. The protein composition and structure of PSDs is known to …
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
… on intracellular interactions with postsynaptic scaffold proteins, however, these interactions do not appear strictly essential to synaptic receptor anchoring. The receptor’s N-terminal domain (NTD) comprises 50 % of the protein, and extends into the synaptic cleft, towards the presynapse, …
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Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
… the cell’s degradation machinery to target proteins such as AurA via targeted protein degradation. This work explores the design and characterisation of bifunctional protein constructs (Polyproxins) with two grafted binding regions to recruit E3 ubiquitin ligases to the target AurA. By …
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Regulation of the Ras Signaling Network in C. Elegans Development
… to tag endogenous LIN-45/Raf and RGL-1/RalGEF proteins. We found that they are recruited to different subcellular compartments during VPC induction. LIN-45 is recruited to the basolateral membrane in presumptive 1˚ cells. RGL-1 is recruited to the apical membrane in presumptive 2˚ cells, and …
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Uncovering the Complexity of RAS Signaling Networks
… to be through inactivation of the KSR1 adaptor/scaffold protein, demonstrating that in addition to promoting signal transmission, scaffold proteins can function to restrict signal propagation. Ras can inactivate IMP through induction of IMP auto-ubiquitination, facilitating KSR-dependent …
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Characterizing the Roles of Sufb and Sufa in Fe-S Cluster Assembly and Trafficking in Suf Pathway
… are essential cofactors in various metalloproteins and are best known for their roles in electron transport as well as redox and non-redox catalysis. Three Fe-S cluster assembly systems: Nif, Isc, and Suf have been identified. The sufABCDSE operon is activated in E. coli to build Fe-S …
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Genes from Arabidopsis involved in iron-sulfur cluster biogenesis
Iron sulfur [Fe-S] proteins are essential components of many major biological processes including electron transport, respiration, photosynthesis, hormone biosynthesis, and environmental sensing. The process of [Fe-S] cluster assembly in living cells is a controlled mechanism that is highly …
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Biomolecular Simulation on Thousands of Processors
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-26T22:39:28Z No. of bitstreams: 1 phillips_James.pdf: 7662495 bytes, checksum: ba41201fd0ec6a43b13f889bf094fcc2 (MD5)
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Isolating, characterizing, and engineering novel Cu-proteins and peroxidases
Metalloproteins are a fascinating class of proteins that function at the heart of several important biological processes including photosynthesis, respiration, and nitrogen fixation. It is even more amazing, considering that nature uses a small set of tertiary structures and metal centers to …
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Identifying Novel Molecular Mechanisms Underlying Lateral Line Organ Development in Sterlet
… 16 encoding, for example, secreted inhibitors, scaffold proteins and co-receptors. In situ hybridisation identified 32 genes expressed in the developing lateral line system. Of these, five (Dner, Fgf10, Ngfr, Cbln18 and Kit) were expressed within developing neuromasts but not AOs, and four …
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Multiplex analysis of protein-lipid and protein-membrane protein interactions utilizing silicon photonic microring resonators
… for many biological functions. When soluble proteins interact with the cell surface, the crowded and complex environment can act as a signaling mechanism and influence blinding and activity. Parsing out the components of the membrane that influence binding is a time consuming process. There …
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Enzymology of lipid metabolism by CYP2J2 as controlled by multiple-ligand binding events
… endothelial tissues. All CYPs are membrane-bound proteins requiring the assistance of a membrane-bound redox partner, cytochrome P450 reductase (CPR). The hydrophobicity of CYP2J2, CPR, and the substrates have made studying this system challenging. We have been able to circumvent many of these …
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Biochemical and structural studies of RNA damage and repair in bacteria
… to restore its function. For example, two proteins in bacteriophage T4, PnkP and Rnl, have been shown to reverse tRNA damage caused by its host’s stress response. In bacteria, numerous RNA repair systems have been identified by bioinformatics and biochemical studies; however, the in vivo …
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