Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Sca-1"”.
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
… a marked increase in a novel UEA-1<sup>int</sup> Sca-1- TEC subset, which is not readily classified as belonging to either the cTEC or mTEC lineage. In addition, low level expression of MHC class II and high-level expression of CD24 suggest that the UEA-1<sup>int</sup> Sca-1- subset contains …
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Avaliação da influência do microquimerismo feto-maternal na miocardite autoimune experimental murina
… obtidas marcadas com anticorpo anti-H-2Kb e anti-Sca-1 para avaliação da presença de células fetais e de precursores da linhagem hematopoiética. Também foi realizada análise histopatológica para a caracterização e mensuração do infiltrado inflamatório. Resultados: Fêmeas nulíparas demonstraram …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
… other typical stem or differentiation markers (Sca-1, CD45, CD31, pax-7, m-cadherin) exists in the EOM. We refer to this population as EOMCD34 cells. The EOMCD34 cells are present in developing muscle, but only maintained in adult EOM, surviving in very aged animals. The EOMCD34 cells are also …
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The α7β1 integrin accelerates exercise-induced myogenesis
… the appearance of multipotent mesenchymal-like (Sca-1+CD45-) stem cells in skeletal muscle. PURPOSE: The purpose of this study was to determine if overexpression of the α7β1 integrin also results in enhanced and/or accelerated myogenesis following a single bout of eccentric exercise. METHODS: …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… I IFN, and IFN-g induced expression of PD-L1 and Sca-1 on naïve murine CD4+ and CD8+ T cells in the absence of TCR stimulation. TCR stimulation induced expression of multiple inhibitory receptors and IL- 27 combined synergistically with TCR stimulation to further upregulate Ly6C, LAG-3, CTLA-4, …
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Perivascular cell contribution to skeletal muscle repair following physiological injury
… muscle-derived mesenchymal stem cells (MSCs; Sca-1+CD45-) accelerate Pax7+ satellite cell expansion and fiber repair during the initial stages of eccentric exercise training in mice. MSCs are a heterogeneous population of perivascular stromal cells, including but not limited to, pericytes, …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… adducts, alter the population of c-kit+Lin—Sca-1—Il7rα— cells and increases 4-hydroxynonenal (4-HNE). Levels of γH2AX, a marker of dsDNA breaks are also increased in fetal liver cell culture following 12.5 µM BQ exposure. Next, using an in vivo CD-1 mouse model of transplacental benzene …
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
… assessed in cardiac tissue, and in an isolated Sca1+ cardiac stem cell population. Satellite cells and PICs were identified and quantified in hind limb skeletal muscle of 3, 10 and 21 day, and 2 year old mice: there was a decline in abundance of both SC and PICs with age. PICs were isolated by …
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Caracterização de células-tronco mesenquimais de camundongos normais e do modelo murino de MPS I
… fluxo, verificou-se que elas eram positivas para Sca-1, CD29, CD44 e CD49e, e eram negativas para CD11b, CD13, CD18, CD19, CD31, CD45, CD49d e Gr-1 Este perfil de moléculas de superfície assemelha-se àquele descrito para a MSC humana, e indica ausência de contaminantes hematopoiéticos. Uma …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… in the progenitor populations (Lgr-6, Lrig-1 and Sca-1) in the Tg mice vs. the stem cell population (CD34 and Keratin15). To investigate the mechanism underlying the increase in the progenitor population at the expense of bulge region KSCs we examined if Stat3C expression was involved in inducing …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
… and more differentiated lineage-negative Sca-1-c-Kit- (LSK-) subpopulation were profiled via bulk RNA-seq, single-cell RNA-seq (scRNA-Seq), and single-cell ATAC-seq (scATAC-Seq). The integrated analysis revealed that PML-RAR expression maintains largely unaltered the overall …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… The addition of PTN to murine PTPRZ-/- c-Kit+Sca-1+Lineage- (KSL) cells caused no expansion of HSCs in culture, suggesting that PTPRZ mediates PTN effects on HSC growth. We subsequently screened for the expression of other receptor PTPs in murine HSCs. Among 21 different receptor PTPs, we …
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Durability and Adhesion of a Model Epoxy Adhesive Bonded to Modified Silicon Substrates
… plasma treatment and silane coupling agent (SCA) derivatization in adhesion promotion for an epoxy bonded to a silicon surface was evaluated in this research. SCAs with different amine functionalities were studied. The oxygen plasma treatment time was varied systematically to achieve a …
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Identification and characterization of epithelial progenitor niches in skin
… on the expression profile of a6 integrin low, Sca-1 negative, CD34 negative cells. The progenitor characteristics of UI keratinocytes were confirmed using skin reconstitution and in vitro colony formation assays. The transcriptional profiling of UI cells led to the identification of Tbc1d10c, …
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… of a 16 wk treadmill exercise program. ADSCs (Sca-1+CD45-) were isolated from epididymal adipose tissue and mRNA was evaluated using high throughput qPCR. While resulting in a total increase in ADSC quantity, HFD decreased the relative quantity of ADSCs and markedly altered gene expression …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… exercise. Lipophilic dye-labeled mMSCs (Sca-1+CD45-) isolated from α7Tg muscle post-exercise via FACS were intramuscularly injected into 3 month old WT recipient mice. Controls were injected with equal volume saline. Mice either remained sedentary or were subjected to eccentric exercise …
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In-vitro-Evaluation der Dentinhaftung und Randschlussqualität eines Komposits, eines säuremodifizierten Komposits und eines kunststoffmodifizierten Glasionomerzementes
… Primer, wie Syntac, Compoglass-SCA und Hytac OSB, als auch für den Haftvermittler EBS, der, Herstellerangaben zufolge nach Total-Etching appliziert werden soll, analysiert werden. Die Bestimmung der Verbundfestigkeit erfolgte mit Hilfe des Ausstoßversuches, die Randanalyse unter …