Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"Satellite cells"”.
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Optimizing Ex Vivo Culture of Satellite Cells
Satellite cells are responsible for regeneration of skeletal muscles. They have the ability to form new muscle fibers and to repopulate satellite cell pool. Transplantation of human satellite cells to muscle dystrophy patients is an aim. To achieve this aim, we must understand mechanisms governing …
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Regulation of satellite cells by extrinsic factors during recovery from exercise in horses
… one of the most critical facets of recovery: satellite cells (SCs). Satellite cells lie adjacent to the myofiber of skeletal muscle, poised to enter the myogenic program and fuse to the nearby muscle after a damaging event. Hepatocyte growth factor (HGF) and insulin-like growth factor-1 …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
… down-regulated and becomes restricted to a few satellite cells (SCs) of select mature muscles. SCs are activated to form new myonuclei during muscle hypertrophy, regeneration and repair. Intrafusal fibers of muscle spindles are thought to persist in a comparatively immature state as, unlike …
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Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… losses in skeletal muscle mass. Mononuclear stem cells, termed satellite cells, are mitotic and serve to donate nuclei to muscle fibers to enable skeletal muscle adaptation. Despite the well-characterized nature of satellite cell activation, proliferation, and differentiation, the underlying …
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Role of the Sh3 and Cysteine-Rich Domain 3 (STAC3) Gene in Proliferation and Differentiation of Bovine Satellite Cells
… in proliferation and differentiation of bovine satellite cells. We isolated satellite cells from skeletal muscle of adult cattle and transfected them with STAC3 small interfering RNA (siRNA) or scrambled siRNA. Cell proliferation assays revealed that STAC3 knockdown had no effect on the …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
Satellite cells are normally a quiescent skeletal muscle stem cell pool that upon activation rapidly proliferate and differentiate to repair damaged muscle fibers. The paired box transcription factor 7 (Pax7) is the canonical biomarker for quiescent, activated, and proliferating satellite cells and …
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Role of Fra-2/AP-1 in Myogenic Progenitor Cells
… expression profiles during myogenesis in C2C12 cells, the expression profile of AP-1 is different among proliferative myoblasts, differentiating myoblasts, differentiated myotubes and reserve cells, indicating context-dependent spatial and temporal roles. We found that the expression profile of …
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The Role of Ring1 and Rnf2 in Skeletal Muscle Regeneration
… in homeostatic and regenerative conditions. Satellite cells, a population of quiescent adult stem cells, maintain the regenerative potential of muscle well into adulthood, but the ability of the cells to maintain this is gradually lost as organisms age. In response to cues following injuries, …
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Cellular and molecular regulation of skeletal muscle regeneration
… mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles of Notch signaling and a novel gene (Bex1) in satellite cell function and skeletal muscle regeneration. ^ The first part of this thesis is to examine how the …
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Aging Skeletal Muscle Plasticity in Exercise and Injury
… after muscular injury. Activity of muscle stem cells, termed satellite cells, is dysregulated with aging which impairs skeletal muscle remodeling and limits plasticity of aged muscle. Aim 1 (Chapter 2) of this dissertation seeks to clarify the debated requirement of satellite cells for …
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The effects of tributyrin and butyrate on equine skeletal muscle
… muscle recovery. Tributyrin and butyrate affect satellite cells and oxidative metabolism in other species. To assess the effects of tributyrin on equine muscle repair, Thoroughbred horses were supplemented tributyrin, and a submaximal exercise test was performed. RNA isolated from the gluteal …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… gene expression was nearly identical in satellite cells isolated from pectoralis major (PM) and biceps femoris (BF) muscles of chicken. Activin-B mRNA level in PM satellite cells was higher than in BF satellite cells at 72 h and 120 h (P < 0.01). IGF-II mRNA level plateaued in PM …
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Genome-wide identification of enhancers, transcription factors, and mechanisms that control skeletal muscle differentiation in cattle
… process whereby the mononuclear muscle precursor cells myoblasts express skeletal muscle-specific genes and fuse with each other to form multinucleated myotubes. Comparing gene expression profiles in C2C12 cells, a widely used model of myoblasts, before and 6 days after induced myogenic …
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The Relationships of Age, Physical Activity Level, Adiposity, and Diet, with Human Satellite Myogenesis, and Metabolism
In healthy individuals, satellite cells are partly responsible for muscle repair and preventing atrophy. Previous studies have linked the loss of muscle mass associated with aging to satellite cell dysfunction, postulating that satellite cell function diminishes with age. New evidence suggests that …
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The role of myostatin during postnatal myogenesis and sarcopenia
… resulting from an impaired propensity of satellite cells to activate and a subsequent decline in myogenesis. Myostatin is a known inhibitor of postnatal satellite cell activation and muscle regeneration, thus muscle mass and regeneration, and satellite cell behaviour were examined in young …
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Muscle Growth and Development in Intrauterine Growth Restricted Pigs
… and -2 SD of litter average respectively. Muscle satellite cell numbers, believed to be the major nuclei source for postnatal muscle growth, were lower in newborn IUGR pigs which could result in reduced muscle hypertrophy potential. In addition, cultures derived from IUGR muscle satellite cells …
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A high-content multiplexed screening platform for the evaluation and manipulation of force and fatigue of adult derived skeletal muscle myotubes in defined serum-free medium
… myotubes derived from adult skeletal muscle satellite cells. The second was to manipulate the inherent muscle parameters such as force output and fatigue of these myotubes by employing exercise regimes or by small molecule application. The importance of serum-free medium use for in vitro …
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
… skeletal muscle-derived interstitial progenitor cells (PICs) are myogenic in vitro, efficiently contribute to skeletal muscle regeneration in vivo, and are self-renewing in vivo whilst also giving rise to satellite cells (Mitchell et al. 2010). They have previously been identified in the mouse …
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Regulation of protein metabolism in skeletal muscle of low-birth-weight neonatal pigs
… dissertation was that dysfunction of myogenic satellite cells and aberrant regulation of protein synthesis and degradation signaling predispose LBWT neonatal pigs to slower postnatal growth. We sought to determine the proliferation and differentiation of satellite cells (SCs) derived from …
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Behaviour of human myoblasts in vitro: role of ageing and inflammatory cytokines
… a specific population of progenitor adult stem cells known as satellite cells in situ and myoblasts ex vivo. The work in this thesis has used a cell culture approach to study the behaviour of human myoblasts and compare the inherent effects of age (by studying myoblasts taken from young and old …
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