Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Sarm1"”.
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Exploring SARM1 as a target to delay programmed axon degeneration
… and turnover, or prodegenerative protein SARM1 can delay programmed axon degeneration. Preclinical studies indicate that complete genetic removal of Sarm1 leads to the strongest protection in vivo after physical transection injury and also prevents perinatal lethality in mice lacking …
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Mutational and Structural Investigation of SARM1, a Protein that Mediates Axon Loss
SARM1 is a pro-degenerative NADase that executes the programmed axon degeneration pathway after nerve injury and in diseases including polyneuropathies. The ARM domain of SARM1 plays a crucial role in regulating its NADase activity. By attenuating this activity, axon degeneration is delayed, making …
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Exploring the role of programmed axon death genes SARM1 and NMNAT2 in human disease
… influence axonal health: the pro-death SARM1 and its upstream regulator, the pro-survival NMNAT2. Notably, complete removal of SARM1 has been shown to rescue injured axons permanently in one case and delay axon loss in many others, alleviating animal models of Parkinson’s disease, …
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… Programmed axon death is regulated by SARM1, a pro-degenerative, multi- functional enzyme that consumes NAD and NADP, with dramatic consequences for neuron energy metabolism. Accumulating evidence in both pre-clinical disease models and in human disease suggests that programmed axon …
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Chronic activation and downstream mechanisms of programmed axon death
… and the pro-degenerative NAD(P)-consuming enzyme SARM1. Over-expression of NMNAT enzymatic activity and removal of SARM1 can significantly delay axon degeneration following numerous neurodegenerative stressors in vitro and in several disease models in vivo, including traumatic brain injury, …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… 1 receptor motif containing protein 1 (SARM1). Meanwhile, Schwann cells activate a distinct transcriptional response, digest myelin using myelinophagy, attract macrophages, and support the survival of damaged neurons and their growth and guidance to their target. The early Schwann cell …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
… mice is unaffected. Here, we examine the role of Sarm1, a component of the Wallerian degeneration pathway, and its interaction with the classical apoptotic cascade in ALS. Consistent with previous work, we find that genetic deletion of Bax delays symptom onset and extends lifespan of SOD-1G93A …