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Showing 1 to 3 of 3 for “"Sarcoplasmic reticulum calcium ATPase"”.
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
… Ca2+ homeostasis, the L-type Ca2+ channels (calcium channel blockers). Other agents, like beta blockers, indirectly target various elements, including sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and ryanodine receptors (RyRs). However, there are no pharmacological agents that directly and …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… There was also profound dysregulation of calcium handling; studies with drug probes revealed that this was caused by excessive calcium intake rather than either sarcoplasmic reticulum calcium ATPase dysfunction or defective buffering of calcium by cardiac myofilaments. These studies …
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Probing cardiac calcium regulation using time-resolved optical spectroscopy.
Sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA) is an integral membrane Ca2+ pump that reuptakes Ca2+ into the lumen of sarcoplasmic reticulum (SR), decreases the cytoplasmic Ca2+ concentration, and initiates relaxation in both skeletal and cardiac muscle. In the heart, SERCA …