Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Sarcomagenesis"”.
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The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis
Sarcomas are cancers of connective tissues, such as bone, adipose and cartilage, and are thought to arise from the aberrant development of the mesenchyme. As such, mesenchymal stem cells are thought to be the cell of origin for sarcomas. Genetic or epigenetic lesions at particular points during the …
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Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis
… To better understand factors underlying sarcomagenesis, we leveraged two rare inherited cancer predisposition syndromes, Li-Fraumeni Syndrome (LFS), and LFS-like (LFSL), both with a high incidence of sarcomas. LFS is caused by mutations in the tumor suppressor gene <em>TP53 …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… oncoprotein FUS-CHOP and linked its role in sarcomagenesis to the radiosensitivity phenotype.</p><p>Here we investigate a molecular mechanism of radiosensitization that couples ionizing radiation to inhibition of translocation-driven sarcomagenesis in myxoid liposarcoma. We performed …
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Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
… been defined using carcinogen-driven models of sarcomagenesis. Using a genetically engineered model of sarcomagenesis, I show that immunoediting requires potent T cell antigens and that lymphocytes drive the evolution of less immunogenic tumors by selecting for antigen loss. Finally, …
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Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
… abrogation during oncogenic K-rasdependent sarcomagenesis suggested that tumor development in the muscle critically depends on early p53 mutation. To test this we generated a Flp-inducible allele of K-rasG12D (K-rasFSF-G12D) that when combined with established reagents for Cre-dependent p53 …