Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Saquinavir"”.
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Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and Drug Administration in the United States for the treatment of HIV infection due to its potent anti-HIV activity. However, some unfavorable properties including low aqueous solubility, low intestinal absorption and …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… controlled release, and painless administration. Saquinavir and Ciprofloxacin, an antiretroviral and an antibiotic respectively, were chosen for their optimal properties, including bioavailability, half-life, and dosage. Saquinavir was encapsulated in the organic phase of biodegradable …
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Die Bedeutung der Proteasehemmer-Plasmakonzentration für das Lipodystrophiesyndrom bei Patienten mit HIV-Infektion unter HAART
… (PI) mit den Substanzen Ritonavir (RTV), Saquinavir (SQV), Indinavir (IDV) und Nelfinavir (NVF) sowie den neueren Substanzen Amprenavir und Lopinavir, die in Kombination mit Substanzen der Nukleosidischen- (NRTI) und Nicht-Nukleosidalen-Reverse-Transkriptase-Inhibitoren (NNRTI) eingenommen …
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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
… delivery of several drugs, including ibuprofen, saquinavir, and clarithromycin. Dissolution experiments were conducted using both ibuprofen and caffeine, and results suggest that SAIB can be used in dosage forms to control release rate. Pharmacokinetic studies in which laboratory rats were dosed …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… HIV/AIDS remains as a major medical challenge. Saquinavir (Saq) is the first anti-HIV PI approved by FDA. Despite of its high anti-HIV potency, its therapeutic efficacy is very limited due to its low oral absorption and bioavailability, which is attributed to extensive cellular efflux mediated …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… inhibitors, such as lopinavir, atazanavir, saquinavir and ritonavir, significantly enhanced the antifungal activity of azoles (fluconazole, voriconazole, itraconazole, and posaconazole) and polyene (AmB). Mechanistic studies showed that the HIV protease inhibitors inhibited the fungal efflux …
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Prescribing patterns of antiretroviral drugs in the private health care sector in South Africa : a drug utilisation review
… ritonavir for period May to August of 2001, and saquinavir mesylate for period September to December of 2001. Nelfinavir has the highest average cost for all three-four month periods of 2002, while didanosine has the highest average cost for all three four-month periods of 2004.
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Caratterizzazione del legame di molecole di interesse farmaceutico alla sieroalbumina umana mediante biocromatografia e dicroismo circolare
… il valore per ritonavir, lopinavir e saquinavir è risultato maggiore del 95%. Questi risultati sono in accordo con dati presenti in letteratura, ottenuti attraverso il biosensore ottico [9]. Inoltre, questi risultati sono coerenti con la significativa riduzione di attività inibitoria …