Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Sample Enrichment"”.
-
Development of a sample enrichment probe method for the gas chromatography-mass spectrometry analysis of hormones in water
A simple sample enrichment probe (SEP) sampling method was developed for the determination of endogenous steroid hormones (estrone, I 7P-estradiol and testosterone) in water using gas chromatography-mass spectrometry (GC-MS). SEPs constructed of thin stainless steel rods of inert material or …
-
INSTRUMENTAL ADVANCES IN CAPILLARY ELECTROPHORESIS MASS SPECTROMETRY FOR TRACE-SENSITIVE PROTEOMICS
… and offers superior resolution and minimal sample consumption, yet its adoption has been limited by historical gaps in instrumental development. This dissertation progresses CE-MS proteomics by developing instrumentation and methodologies to promote sensitivity, robustness, scalability, …
-
Capillary Electrophoretic Technologies for Single Cell Metabolomics
… with the small volumes of the cellular samples, as well as its ability to carry out online sample enrichment.
-
High-Frequency Electronics for Contactless Dielectrophoresis
The field of sample enrichment is currently receiving a large amount of attention because it is essential to reduce the time required for many laboratory processes. Dielectrophoresis, or the motion of a polarized particle in the presence of a non-uniform electric field, has emerged as a promising …
-
A NOVEL DROPLET-BASED PLATFORM FOR TUMOR SINGLE-CELL ENCAPSULATION AND METASTATIC MULTICELLULAR CLUSTER MODELLING
… It incorporates inertial focusing and on-chip sample enrichment techniques to enhance cell loading efficiency and reduce variability. Functional analysis revealed the influence of biophysical stress on viability, migration, and expression of adhesion and survival markers such as plakoglobin and …
-
Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… and high sensitivity, UPLC-MRM is widely used in sample bioanalysis for pharmacokinetics. Recently, interest into human endogenous protein quantification using targeted quantitative proteomics has increased. These quantification measurements are useful in many aspects of drug discovery and …
-
Extraction and analysis of pharmaceutical residues in environmental samples using SPE with LC-MS/MS
… to all the developed methods, a SPE sample enrichment procedure was also developed focusing upon either off-line formats using modern hydrophilic lipophilic balanced polymeric phases or the use of column switching, whereby short reversed-phase monolithic micro-columns were applied as …
-
MRI Measures of Neurodegeneration as Biomarkers of Alzheimer's Disease
… efficacy and mechanism of action, as well as for sample enrichment with patients most likely to rapidly progress towards AD.
-
Lab on a chip rare cell isolation platform with dielectrophoretic smart sample focusing, automated whole cell tracking analysis script, and a bioinspired on-chip electroactive polymer micropump
… chips, is a rapid process with minimal sample preparation, and allows for immediate downstream recovery. This platform is highly competitive compared to other cell sorting techniques and is one of the only platforms to sort cells based on phenotype, allowing for the isolation of unique …
-
In Situ Enrichment and Epitaxial Growth of 28Si Films via Ion Beam Deposition
… this question, specifically in terms of the enrichment. Secondary requirements for ideal 28Si films that are also pursued are crystalline perfection and high chemical purity. I report on the production and characterization of 28Si thin films that are the most highly enriched of any known 28Si …