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Showing 1 to 7 of 7 for “"Salvinorin"”.
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Synthetic Work Towards Salvinorin A
Salvinorin A is the active compound in the plant Salvia divinorum, commonly known as salvia. It is a highly selective kappa opioid agonist, which gives it potent hallucinogenic and potent analgesic properties. The natural compound was isolated and characterized in 1982, and a multitude of …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
<p>The field of salvinorin chemistry represents a novel and emerging field of opioid research. The novelty is derived from the lead pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in …
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Synthesis towards Salvinorin Scaffold to Develop a Potential Pain Therapeutic and Selective, Potent Kappa Opioid Ligands
… cross affinity to opioid receptor subtypes, Salvinorin A has emerged as a very unique alkaloid. Salvinorin A is a non-nitrogenous alkaloid that selectively binds to the kappa opioid receptor subtype, implicating it as a potential target for development as a pain therapeutic for chronic …
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
Part I: Salvinorin A is the main active component of the plant Salvia divinorum. Salvia divinorum is native to the Mazatec region in Northern Oaxaca, Mexico. It has been used by local Mazatec Indians for its hallucinogenic properties in ritual divination and healing ceremonies. It is the first …
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… In Part II of this study, 3D-QSAR studies of salvinorin A analogs as kappa opioid (K) receptor agonists were performed. Salvinorin A is a naturally-occurring diterpene from the plant Salvia divinorum which activates the kappa opioid receptor (KOR) selectively and potently. It is the only known …
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Evaluating preference-seeking and aversive qualities of Salvia divinorumand Mitragyna speciosa
… place aversion (Salvia divinorum). Because salvinorin A is well characterized as the major psychoactive compound, we did not study an extract fraction for S. divinorum. Following apparatus habituation and quantification of baseline compartment preference, male Sprague-Dawley rats were given …
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Understanding ligand binding, selectivity and functions on the G protein-coupled receptors: A molecular modeling approach
… of the κ-opioid receptor covalently bound to a salvinorin A derivative (agonist) was attempted via molecular dynamics simulations. Although the obtained molecular model lacked the signature ‘agonist-like’ conformations, the result provides a template for such studies in the future.</p>