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Showing 1 to 5 of 5 for “"Salvia divinorum"”.
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… A is the main active component of the plant Salvia divinorum. Salvia divinorum is native to the Mazatec region in Northern Oaxaca, Mexico. It has been used by local Mazatec Indians for its hallucinogenic properties in ritual divination and healing ceremonies. It is the first non-alkaloid …
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Evaluating preference-seeking and aversive qualities of Salvia divinorumand Mitragyna speciosa
… the other expected to produce place aversion (Salvia divinorum). Because salvinorin A is well characterized as the major psychoactive compound, we did not study an extract fraction for S. divinorum. Following apparatus habituation and quantification of baseline compartment preference, male …
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Synthetic Work Towards Salvinorin A
Salvinorin A is the active compound in the plant Salvia divinorum, commonly known as salvia. It is a highly selective kappa opioid agonist, which gives it potent hallucinogenic and potent analgesic properties. The natural compound was isolated and characterized in 1982, and a multitude of …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in that it is the first known non-nitrogenous KOR subtype-selective agonist, exhibits a comparatively safe physiological profile with no reports of toxicological effects …
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… a naturally-occurring diterpene from the plant Salvia divinorum which activates the kappa opioid receptor (KOR) selectively and potently. It is the only known natural non-nitrogenous agent active at the human KOR. Salvinorin A may represent a novel lead compound with possible potential in the …