Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Salmonella virulence"”.
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
Salmonella serovars cause a wide variety of diseases ranging from mild gastroenteritis to life threatening systemic infections. An important step during a S. typhimurium infection is the invasion of non-phagocytic epithelial cells. Invasion is mediated by a Type Three Secretion System (TTSS), which …
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Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… how microbiota directly antagonizes pathogen virulence is less studied. In particular, gut microbiota produces large amounts and varieties of small molecules that may impact both host immunity and pathogen virulence. In this thesis, I describe how fatty acids, derived from both gut microbiota …
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An investigation of the development and evaluation of online approaches for improved kinaesthetic learning in science
… E. coli, DNA transcription and translation, and Salmonella virulence factors. A mixed-methods study was conducted including three pilot studies, three randomised control trials and two sub-studies. Study participants included over 100 students from a variety of secondary schools (typically aged …
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Structural and Functional Characterization of B. Anthracis Udp-Glcnac 2-Epimerase and Salmonella Secreted Effector I
… cell-wall enzyme UDP-GlcNAc 2-Epimerase and the Salmonella secreted virulence effector SseI. UDP-GlcNAc 2-Epimerase is an essential B. anthracis enzyme required for formation of the peptidoglycan cell wall precursor UDP-ManAc. We have solved the epimerase's crystal structure to 1.70 Å, explaining …
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
Salmonella Typhimurium survives and replicates in host macrophages. The bacterium produces two Cu-Zn periplasmic superoxide dismutases, SodCI and SodCII. Although both enzymes are expressed during infection, only SodCI contributes to virulence in the mouse by combating phagocytic superoxide. We …
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Characterization of Bacterial Metabolites Involved in Host Pathogen Resistance
… or by directly inhibiting pathogen growth and virulence. Although the abundance and diversity of bacterial metabolites in the intestine is appreciated, the majority of intestinal bacteria and bacterial products have not been characterized in the context of microbiota-mediated pathogen …
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Regulation of virulence in Salmonella enterica
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen, capable of causing disease in a variety of animal hosts. Both invasion of the host intestinal epithelial cells, and survival and replication in host macrophages are required for the successful establishment of the …