Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Salmonella Typhimurium VNP20009."”.
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Novel Perspectives on the Utilization of Chemotactic Salmonella Typhimurium VNP20009 as an Anticancer Agent
… and drug delivery potential for decades. Salmonella Typhimurium VNP20009 was derived from the parental strain 14028 through genetic modification and tumor targeting ability, being well studied for anticancer effects in mice. In 2001 Phase 1 Clinical Trials, patients diagnosed with melanoma …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Design, Modeling, and Characterization of Transport and Sensing
… and Bifidobacterium) and gram-negative (e.g. Salmonella Typhimurium and Escherichia coli) bacteria have been shown to possess the innate ability to preferentially colonize tumor tissues. The overall goal of this dissertation is to characterize the transport and sensing of Bacteria-Enabled Drug …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Development, Characterization of Intratumoral Transport and Modeling
… develop a novel tumor treatment system based on Salmonella Typhimurium VNP20009 (genetically modified for preferential tumor colonization and attenuation) coupled with biodegradable copolymer, poly(lactic-co-glycolic acid) nanoparticles, hereafter referred to as NanoBEADS (Nanoscale Bacteria …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… within the tumor microenvironment. Attenuated Salmonella Typhimurium VNP20009 (ST) exhibits ~10³-10⁴-fold tumor selectivity with respect to liver and spleen. It has a favorable clinical safety profile but remains inefficacious due to poor colonization. Our lab previously showed that …