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Showing 1 to 16 of 16 for “"Salmonella Pathogenicity Island"”.
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Regulation of the Salmonella Pathogenicity Island 1 Type Three Secretion System
"The invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium is mediated by a Type Three Secretion System (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 TTSS injects effector proteins into the cytosol of host cells where they promote actin …
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Regulation of Salmonella pathogenicity island I through the hilD mRNA 3' untranslated region
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Integration of small RNAs in the control of Salmonella pathogenicity island 1(SPI1)
Salmonella induces inflammatory diarrhea and epithelial invasion using a Type Three Secretion System (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). The SPI1 T3SS directly injects several effector proteins into host cytosols, resulting in host actin rearrangement and engulfment of the …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
Salmonella Pathogenicity Island 1 (SPI1) encodes a Type-3 secretion system (T3SS) essential for Salmonella invasion of intestinal epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory …
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Coordinated regulation of the flagellar, Salmonella pathogenicity island 1, and the type I fimbriae gene networks in Salmonella typhimurium
… from the cell. Using the food-borne pathogen, Salmonella, as a model organism, we try to investigate how cells encode strategies in networks to optimally control cellular behavior. Salmonella, on ingestion with contaminated food, swims in small intestine using propeller-like structures, …
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Characterization of the type VI protein secretion system encoded in the Salmonella pathogenicity island 19 and its role in the pathogenicity of serotypes Gallinarum and Enteritidis
El genero Salmonella comprende a mas 2,500 serotipos conocidos distribuidos en dos especies: enterica y bongori. Estos serotipos difieren mucho en términos de patogenicidad y especificidad hospedero. Dos serotipos de Salmonella entérica son de especial relevancia: los serotipos Gallinarum y …
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Identification and Characterization of SitABCD, a Metal Ion Transporter of Salmonella Typhimurium
Salmonella typhimurium is an invasive pathogen that causes diseases ranging from mild gastroenteritis to enteric fever. During the infection process, S. typhimurium induces a number of virulence genes required to circumvent host defenses and/or acquire nutrients in the host. We have used the IVET …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
Salmonella enterica serovar Typhimurium injects a set of effector proteins into the host cell cytoplasm via the Salmonella Pathogenicity Island I (SPI1) type III secretion system (T3SS) to induce inflammatory diarrhea and bacterial uptake into intestinal epithelial cells. The master SPI1 regulatory …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
Salmonella enterica species are intracellular bacteria causative agents of gastroenteritis and typhoid fever in humans. Pregnancy poses an increased risk of severe Salmonellosis in many mammalian species contributing to miscarriage and/or maternal illness. Previous studies indicated that Salmonella …
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Mucin and mucin glycans alter behaviorof mucosal pathogens
… My second project examines the primary pathogen Salmonella enterica serovar Typhimurium, which must pass through the mucus barrier before reaching and invading host cells. I demonstrate that mucin and mucin glycans block S. Typhimurium’s ability to infect host epithelial cells. I further reveal …
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
Salmonella serovars cause a wide variety of diseases ranging from mild gastroenteritis to life threatening systemic infections. An important step during a S. typhimurium infection is the invasion of non-phagocytic epithelial cells. Invasion is mediated by a Type Three Secretion System (TTSS), which …
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IDENTIFICATION AND CHARACTERIZATION OF THE 'GUT VASCULAR BARRIER'
… we show that GVB integrity could be modified by Salmonella typhimurium infection. Indeed, upon infection ECs up-regulated the expression of PLVAP, that has been previously used as a marker of immature/damaged vascular barrier in the brain, and up-regulated caveolin-1, the major component of …
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Mechanisms of signal integration: Regulation of the SPI1 T3SS
Salmonella must rapidly adapt to various niches in the host during infection. Relevant virulence factors must be appropriately induced, and systems that are detrimental in a particular environment must be turned off. Salmonella infects intestinal epithelial cells using a type 3 secretion system …
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Regulation of virulence in Salmonella enterica
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen, capable of causing disease in a variety of animal hosts. Both invasion of the host intestinal epithelial cells, and survival and replication in host macrophages are required for the successful establishment of the …
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Role of Salmonella enterica subspecies enterica serovar Enteritidis pathogenicity island-2 in chickens
Salmonella enterica subspecies enterica serovar Enteritidis (S. Enteritidis) has been identified as a significant cause of salmonellosis in humans. Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) each encode a specialized type III secretion system (T3SS) that enables Salmonella to …