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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Salbutamol"”.
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Effects of salbutamol on potassium and exercise performance
Salbutamol is a β2 adrenergic agonist widely used for the treatment of asthma and known to reduce plasma potassium concentration [K+]. The International Olympic Committee had been concerned that salbutamol may give an inequitable advantage to athletes. However, little work has investigated whether …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
… presence of surfactants and polymeric additives. Salbutamol sulphate (SS) was used as the model drug compound. Several candidate antisolvents were screened via studying particle morphology, particle size and agglomeration of crystal products in order to determine the proper antisolvent used in the …
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Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs
… in-vitro and in-vivo performance of three salbutamol metered dose inhalers (MDIs): Ventolin Evohaler (Evo), Airomir (Airo) and Salamol. In the in-vitro studies, critical quality attributes of the MDI using an Andersen cascade impactor (ACI) were examined and included measurement of fine …
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Ergogenic Effects of Intake of Salbutamol, Caffeine and Theobromine on Non-Asthmatic Subjects
… (WADA) permits asthmatic athletes to use inhaled salbutamol with an accumulated dosage not exceeding 1600 µg over a 24-hour period. A key driver for the inclusion of β2-agonists on the WADA restricted list is associated with its potential impact on athletic performance according to previous …
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The impact of acute and chronic administration of short-acting β2-agonists on urinary pharmacokinetics and athletic performance
… is unknown. Whilst the short-acting β2-agonist salbutamol is permitted in and out of competition due to a known pharmacokinetic response, no urinary threshold has been established for the use of the alternative short-acting β2-agonist terbutaline. The purpose of study 1 was to investigate the …
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Response of Peripheral Blood Lymphocytes from RAO-affected Horses to b2-Agonist Stimulation
… and airway inflammation. β2-agonists like salbutamol are used as treatment, promoting airway smooth muscle (ASM) relaxation and bronchodilation. In addition to ASM, inflammatory cells express the β2-adrenoreceptors (β2-AR). In other species, β2-agonists promote peripheral blood …
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A systematic review of the symptomatic treatment of the cough in whooping cough
… is due to the paroxysmal cough. Corticosteroids, salbutamol (a β₂- adrenergic stimulant), and pertussis-specific immunoglobulin have been proposed as standard treatment for the cough. Antihistamines have also been administered. No systematic review of the effectiveness of any of these interventions …
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A retrospective review of all children admitted with acute severe asthma to the paediatric intensive care unit, Red Cross War Memorial Children's Hospital between 2009-2019.
… Half of the patients were loaded with IV salbutamol (n=96; 53,3%) and about a third (n=61; 34%) received a salbutamol infusion before admission to PICU. Similar proportions received nebulisations and steroids in PICU, 34 patients (19%) received magnesium sulphate again in PICU and a total …
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Analysis of patient drug usage trends in the POYC scheme
… atorvastatin (34), bendroflumethiazide (32), and salbutamol (30). There has been an increase in the usage for 8 out of 10 drugs. The greatest rise observed was of atorvastatin, with 2,856 tablets dispensed in 2019 from 1232 dispensed tablets in 2017, a 131.8% increase. Omeprazole and salbutamol …
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The rational design of drug crystals to facilitate particle size reduction. Investigation of crystallisation conditions and crystal properties to enable optimised particle processing and comminution.
… and crystal variants of ibuprofen and salbutamol sulphate (size, morphology and crystal quality) were investigated in order to determine those factors with greatest impact on post-micronisation measures of particle quality including particle size, degree of crystallinity and surface …
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Physiological Response of uterine muscle to aqueous root extract of Steganoteania Araliacea Hochst (Herbal''Pitocin'') in Rats
… antagonists; atropine (AT), and indomethacin and salbutamol (SBM) respectively. The effect of these reference agonists with their corresponding antagonist and that of aqueous extract of SAE on non-pregnant rat uterus pre-treated with 1 mg/kg stilboesterol for 24 h and on the pregnant rat uterus …
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Design and development of an automated metered dose inhaler (MDI) for asthmatic patient
… the infant to breathe in the medication known as salbutamol. Current asthma spacer does not provide systematic way of monitoring and displaying the percentage value of the propellant. Furthermore, user non-compliance is found to contribute towards longer recovery rate. Therefore, this product is …
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Improving the care of infants with bronchiolitis : Using knowledge translation to close the evidence-practice gap
… and hydration), and do not recommend use of salbutamol, antibiotics, glucocorticoids, adrenaline or ordering chest radiographs. Despite evidence that these five therapies and management processes have no benefit, variation in clinical practice occurs with infants receiving non-evidence-based …
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Effects of organophosphate esters on blood vessels: a physiological, pharmacological, and histological assessment of involvement in organophosphorus-induced delayed neuropathy (OPIDN)
… α1 agonist, phenylephrine; and the β2 agonist, salbutamol). These responses were compared before and 1, 3, 7, and 21 days after hens were administered cyclic phenyl saligenin phosphate (PSP, 2.5 mg/kg i.m.), an OP that induces OPIDN but does not significantly inhibit acetylcholinesterase …
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Use of nanoemulsion liquid chromatography (NELC) for the analysis of inhaled drugs. Investigation into the application of oil-in-water nanoemulsion as mobile phase for determination of inhaled drugs in dosage forms and in clinical samples.
… chemical structure, such as terbutaline and salbutamol. A nanoemulsion mobile phase containing a non-ionic surfactant (Brij-35) with ethyl acetate, butanol and a phosphate buffer, was, however, successful in achieving a base line separation, and the method was validated for simultaneous …
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Manipulation of carrier particles for inhalation
… also produced. The short-acting betas- agonist, salbutamol sulphate, was subsequently used to assess the relative performance of these materials as drug carriers in a dry powder inhaler (OPI). The main aim of the research was to establish whether a relationship exists between the surface …
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The effect of genetic variation on asthma severity and treatment in childhood
… daily or more) as required doses of inhaled salbutamol. This effect is not observed on participants with asthma who are not exposed to ß2-agonist on a daily basis. 5. I have shown that the Arg16Arg variant status may be associated with worse airway obstruction, as measured by the FEV1/FVC …
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