Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Sactipeptide"”.
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Elucidation and control of substrate recognition during RiPP biosynthesis
… was combined with enzymes from the sactipeptide and lanthipeptide RiPP classes to create new-to-nature hybrid RiPPs. These hybrids provide insight into biosynthetic timing and enzyme compatibility and establish a general platform for the engineering additional hybrid RiPPs.
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Investigating and engineering the post-translational modifications in RiPP natural product biosynthesis (I) Thiopeptides (II) Sactipeptides
… from thiopeptide work and into the realm of sactipeptides, which feature a radically-installed thioether linkage between a Cys donor residue to the Cα of an acceptor residue. Using bioinformatics, we surveyed the entire family and found a novel sactipeptide featuring a previously-unseen …
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Biomolecular NMR studies of the structure and biosynthesis of RiPP natural products
… RiPPs discovered through genome mining. The sactipeptide huazacin was characterized by HRMS/MS and NMR spectroscopy and was shown to have bioactivity against Clostridia sp. Utilizing sequence homology and HRMS/MS, the natural product freyrasin was hypothesized to contain unprecedented …
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Investigation of radical SAM-mediated thioether installation in RiPP natural products
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01