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Showing 1 to 20 of 60 for “"SYK"”.
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Regulation of Syk activity in GPVI-mediated platelet activation
… in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this physiological process suggests regulation of its activity is required to maintain the platelets response to collagen within physiological …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… tyrosine kinases and serine/threonine kinases. Syk (spleen tyrosine kinase) is an important non-receptor tyrosine kinase present in platelets and plays an important role downstream of GPVI-FcR gamma chain receptor complex activation. We studied the effects of curcumin (diferuloylmethane), which …
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Untersuchungen zur physiologischen Rolle der Proteintyrosinkinase Syk in humanen Brustepithelzellen
Die Proteintyrosinkinase (PTK) Syk wird ubiquitär in hämatopoetischen Zellen exprimiert und ist für die Weiterleitung von Signalen aktivierter Immunrezeptoren unerlässlich. Eine biologische Funktion von Syk wurde auch außerhalb hämatopoetischer Zellen postuliert. In Anbetracht dessen sollten in der …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… in the functions of the protein-tyrosine kinase SYK, which is important both for macrophage activation and phagocytosis, might underlie much of this pathology. Recent evidence from our lab indicates that SYK can associate with stress granules, ribonucleoprotein particles that form in stressed …
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Disorder in holographic field theories: inhomogeneous geometries, momentum relaxation and SYK models
… the duality. We discuss the Sachdev-Ye-Kitaev (SYK) model, a disordered many-body model with distinctive black hole-like properties. We provide analytical and numerical evidence that these holographic properties are robust against a natural one-body deformation for a finite range of parameters. …
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Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer
<p>The Syk protein-tyrosine kinase, a well-characterized modulator of immune recognition receptor signaling, also plays important, but poorly characterized, roles in tumor progression, acting as an inhibitor of cellular motility and metastasis in highly invasive cancer cells. Multiharmonic atomic …
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
Spleen tyrosine kinase (SYK) regulates mitogenic signaling, inflammatory responses and cell fate in a number of diverse cell types. KRAS is a proto-oncogene that controls cell growth and proliferation through several mitogenic pathways. In pancreatic cancer, KRAS is frequently mutated, resulting in …
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B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
… at least one kinase. The protein tyrosine kinase syk is one of the major endogenous substrates of this kinase activity. Moreover, we demonstrated that the in vitro phosphorylation of syk is induced synergistically by IL-4 and anti-immunoglobulin. We subsequently isolated a cDNA clone of human syk …
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SYK promotes TGF-beta-induced P-body clearance in breast cancer cells through the enhancement of autophagy
<p>SYK is a protein tyrosine kinase that plays an essential role in the development and activation of immune cells. Its expression, however, is not limited to immune cells. SYK is expressed in a variety of epithelial cell types and epithelial-derived tumors. Reports regarding the role of SYK …
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… the contribution of the spleen tyrosine kinase (SYK) in AD pathobiology. Syk is wellknown for its involvement in B-cell receptor (BCR) signaling but our previous data have demonstrated that SYK is also involved in tau yperphosphorylation and A-beta production, therefore suggesting that SYK could …
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual …
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Biophysical studies of the allosteric regulatory mechanism of Syk tandem SH2 domains interacting with immunoreceptor tyrosine-based activation motifs
<p>The non-receptor spleen tyrosine kinase (Syk) is an important player in signal transduction from immunoreceptors to various downstream targets. It is widely expressed in both haematopoietic and epithelial cells. Syk disorder is closely related with many inflammatory and autoimmune diseases, as …
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UNIQUE ALLOSTERIC MECHANISM REGULATING PROTEIN-PROTEIN INTERACTION THROUGH PHOSPHORYLATION: A CASE STUDY OF THE CONFORMATIONAL CHANGES IN THE SYK TANDEM SH2 PROTEIN
Spleen tYrosine Kinase (Syk) is one of the crucial signaling proteins involved in the development of immune cells and the initiation of inflammatory responses. Syk is a 72-kDa kinase comprising three folded domains: two SH2 domains and a catalytic domain. The tandem SH2 domains connected by linker …
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Investigation of the potential of Spleen Tyrosine Kinase (SYK) as a target for host-directed therapy during mycobacterial infection in macrophages
… pathology caused by Mtb. Spleen tyrosine kinase (SYK) plays an important role in innate immune signalling. It is expressed on innate immune cells such as macrophages. Macrophages play a critical role in thepathophysiology of TB. They are the first responders to Mtb infection and are phagocytic …
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Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
… through an ITAM pathway by activation of Src and Syk kinases leading to activation of PLC\(_y\)2. CLEC-2 has been shown to activate platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and Syk kinases, but shows a partial rather than an absolute dependence on …
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Development of Tyrosine Kinase Peptide Biosensors and Methods for Detection
… incorporation of phosphate.</p> <p>An artificial Syk substrate peptide was developed and incorporated with other functional modules to produce a Syk biosensor. These modules included a biotin-tag for affinity capture, a photo-cleavable amino acid to allow release of the substrate from the delivery …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… family kinase (SFK) inhibitor, PP2, or when Syk is inhibited. PP2 abolished phosphorylation of Syk and Phospholipase Cγ−2. Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation by collagen and CLEC-2 receptor agonists. Platelet activation by …
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The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
… <br>protein tyrosine kinases, Lyn and Syk. The phosphorylation of SHIP by Syk, but not that by <br>Lyn, was strictly dependent on the presence of an integer BCR complex, indicating that Syk <br>requires BCR expression for the phosphorylation of SHIP. Furthermore, the absence of proper …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
… by Abl family kinases is mediated in part by the Syk kinase. Loss of Abl and Arg expression or treatment with Abl inhibitors reduced Syk phosphorylation in response to Fcgamma receptor ligation. The link between Abl family kinases and Syk may be direct as purified Arg kinase phosphorylates Syk in …
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