Global ETD Search
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Showing 1 to 18 of 18 for “"SWI/SNF complex"”.
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STRUCTURAL AND FUNCTIONAL DELINEATION OF SUBUNITS AND DOMAINS IN THE SACCHAROMYCES CEREVISIAE SWI/SNF COMPLEX
… these domains and subunits, whether they affect complex formation, substrate affinity or a critical step in remodeling. If they do affect remodeling, what is the structural basis of the regulatory activity. In this study, these questions have been addressed using the prototype remodeler SWI/SNF …
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Identifying the Role of Transcription Factor RFX3 in 9PDeletion Syndrome
… to intellectual disability and part of the SWI/SNF complex, was identified as a direct target of RFX3 in the commonly deleted region of chromosome 9p. Notably, the combined deletion of RFX3 and SMARCA2 led to greater dysregulation of SMARCA2 expression and SWI/SNF complex components than the …
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The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology
… carcinoma. Although these processes are complex and not completely understood, specific genetic and epigenetic factors that drive aspects of this pathophysiology can shed further light on both how these diseases develop and on how normal, healthy regeneration differs from liver disease. …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… ATP-dependent chromatin remodelling complexes modulate nucleosome structure, positioning and chromatin de-compaction and are involved in gene activation and repression. SWI/SNF ATP-dependent chromatin remodelling complexes contain either BRG1 or BRM as the core ATPase together with …
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Molecular Mechanisms Underlying Aerobic Respiration and Heme Regulation in Yeast
… them were proteins of the chromatin remodeling SWI/SNF complex. Six proteins of the SWI/SNF complex- Swi3, Snf5, Snf6, Snf11, Snf12 and Swp82 relocalized under hypoxia. One of the objectives of this dissertation was to study the mechanism of regulation of cellular bioenergetics and respiration …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… analysis revealed that SOX4 targets numerous SWI/SNF complex subunits and co-binds with NEUROG2 to enhance the expression of diverse neurogenic factors. The overexpression of SWI/SNF chromatin remodeling factors or treatment with small molecules that modify chromatin accessibility enhanced …
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Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
SWI/SNF related ATP-dependent chromatin remodelling complexes act to regulate chromatin accessibility, ensuring that genes are regulated appropriately. Components of the complexes are mutated in approximately 20% of human cancers. PBRM1 is one of defining subunits of the PBAF subtype of SWI/SNF …
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The TAZ Protein Interactome in Striated Muscle
… regulators were also represented: NuRD complex, FACT complex, and SWI/SNF complex. We focused on characterizing the TAZ interaction with the Wnt co-repressor TLE3 in myogenic cells. In myogenic cells, TAZ and TLE3 interact and co-localize within the nucleus. Functionally, TAZ and TLE3 …
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Trim28 Interacts With Ezh2 to Regulate Its Activity
… TRIM28 regulation of EZH2 association with SWI/SNF complex might contribute to this process. Collectively these data indicate that EZH2 and TRIM28 regulate breast cancer stem cell maintenance by transcriptional regulation of CXCR4 gene expression.</p> <p>In part two, TRIM28 is overexpressed …
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SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION
… Southern Illinois University Carbondale. TITLE: SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION MAJOR PROFESSOR: Dr. Blaine Bartholomew The SWI/SNF complex disrupts and mobilizes chromatin in an …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… proteins including 53BP1, MDC1, NBS1, and the SWI/SNF complex to the DSB region to promote DNA repair. <em>BRIT1</em> copy number deficiency correlates with increased genomic instability in ovarian cancer specimens and breast cancer cell lines. Here, we propose that additional functions of …
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Regulation of mammalian SINE transcription
… be occupied by HDAC1, HDAC2 and a component of SWI/SNF complex, Brahma. Human Alus were also found to be occupied by components of two corepressor complexes, SIN3 and NuRD. Whether MBD proteins repress SINE transcription in a DNA methylation-dependent manner was further investigated using …
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Investigating upstream regulators of FOXA1 in breast cancer
… factors and modulates FOXA1 interactions with SWI/SNF complex members and other nuclear cofactors. PIGS depletion also impacts chromatin binding of both FOXA1 and ERα. To identify factors influencing FOXA1 protein levels, we conducted focused CRISPR screens coupled to FACS sorting based on …
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
… processes such as transcription and replication. SWItch/Sucrose Non-Fermenting (SWI/SNF) complexes are a family of chromatin remodellers that are conserved across eukary- otes. Mutations in subunits of SWI/SNF complexes cause a multitude of different developmental disorders including Coffin-Siris …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
… chromatin state marked by components of the SWI/SNF complex. In contrast, genes necessary for S and M phase progression have lower transcription levels but remain within a permissive euchromatin state. Finally, specific loci are marked by an increase in Polycomb-bound domains in quiescence, …
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Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinoma
… suggested that OAC may harbour large numbers of complex rearrangements and that reflux may contribute to this. I have developed and validated a pipeline for the sensitive and specific detection of structural variants in cancer. As part of this I have explored the factors contributing to false …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
Chromatin is highly regulated nucleoprotein complex facilitating the dynamic balance between genome packaging and accessibility. The central workhorses regulating the dynamic nature of chromatin are ATP-dependent chromatin remodelers- ISWI, SWI/SNF, INO80, and CHD/Mi2. All chromatin remodelers …
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Understanding The Pathogenesis of Renal Medullary Carcinoma
<p>Renal medullary carcinoma (RMC) is a lethal cancer that predominantly affects young individuals with sickle cell trait (SCT). It is not currently understood why RMC only affects certain individuals with SCT. We found that patients with RMC more frequently participated in high-intensity exercise …