Global ETD Search
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Showing 1 to 10 of 10 for “"SUMO-1"”.
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Lokalisation des antiviralen Mx1 Proteins und seiner assoziierten Proteinkinase in nukleären Einschlusskörperchen
… um nukleäre Proteine, darunter Komponenten des SUMO-1-Systems und der sogenannten PML Nuclear Bodies (PML NBs). <br>Im Rahmen der vorliegenden Dissertation konnte durch konfokale Mikroskopie eine enge morphologische Assoziation von Mx1 zu den Proteinen der PML NBs und des SUMO-1-Systems gezeigt …
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Regulation of mGluR7 trafficking by SUMOylatio in neurons
Protein SUMOylation is a post-translationalmodification by which SmallUbiquitin-like MOdifier (SUMO) proteins are covalently linked to the lysine residues of target proteins via an enzymatic cascade. It has been reported that SUMOylation of synaptic proteins plays important regulatory roles in …
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Auswirkungen und zugrunde liegende Mechanismen von hormetischen Stimuli auf das Reparatur- und Regenerationsvermögen der Haut
… Veränderungen von Proteinen durch SUMO (small ubiquitin related modifier). Die Ergebnisse zeigen, dass (1) Keratinocyten empfindlicher auf proteasomalen Stress reagieren als Fibroblasten, (2) MG132 in beiden Zelltypen zu einer Induktion von Hsps und MA führt, (3) die …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… at lysine 33 by small ubiquitin-like modifier-1 (SUMO-1). Sumoylation is facilitated by direct interaction with the E2 conjugating enzyme Ubc9 and increases following T cell stimulation. In addition, c-Maf physically interacts with p65/RelA. This interaction is dependent on the DNA binding domain …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… that MafA was post-translationally modified by SUMO-1/2 (small ubiquitin-like modifier) mainly at lysine 32. Low glucose starvation or hydrogen peroxide stimulation increased sumoylation of MafA. Forced sumoylation of MafA reduced its transcriptional activity towards the insulin gene promoter …
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Host Proteins Interact with the Hiv-1 Core to Facilitate and Restrict
… HIV-1. Additionally, in AIM 2 I demonstrate that SUMO-1 and SUMO interacting motifs (SIMs) are important for TRIM5á restriction of HIV-1 and TRIM5á stability.</p><p>As mentioned before, the viral capsid is the determinant of TRIM5-mediated restriction. The capsid houses the viral RNA and other …
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Uncovering the Complexity of RAS Signaling Networks
… to the nucleus. We also demonstrate that SUMO-1 exerts negative effects on IMP inhibitory activity. Additionally, a predicted UBP-ZnF was examined for regulation of autoubiquitination. Together, these data point to the existence of multiple regulatory inputs that control IMP activity. …
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Functional Analysis of the Human SMC5/6 Complex in Homologous Recombination and Telomere Maintenance
… is a ligase for small ubiquitin-like modifier (SUMO). Depletion of MMS21 by RNA interference (RNAi) sensitizes cells toward DNA damageinduced apoptosis. This hypersensitization of MMS21-RNAi cells is not due to a defect in DNA damage-induced cell cycle checkpoint, but rather in the kinetics of …
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
… studies have shown that 5-HT1A Rs can be SUMOylated by SUMO1 in rat brain areas such as cortex, hypothalamus and hippocampus. Studies have also shown that SUMOylated 5-HT1A Rs cannot bind to agonist. In addition, it was reported that SUMOylation of 5-HT1A Rs in the hypothalamic membrane …
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THE PHD FINGER OF SP140: A STRUCTURAL AND FUNCTIONAL STUDY
… might be attributed to this domain, such as a SUMO E3 ligase activity towards the adjacent bromodomain. This hypothesis was supported by the presence of a typical KxE SUMOylation site at the N-terminus of the Sp140 bromodomain (761-LKCE-764) and by recent data on KAP1 PHD finger, which …