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Showing 1 to 5 of 5 for “"SUMO Proteins"”.
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Biochemical Characterization of the Activity and Specificity of ULP1 Family Members
The reversible posttranslational modification, SUMO, modulates the activity of a diverse set of target proteins. Conjugation machinery charges the processed-SUMO so that it can be linked via an isopeptide bond to a target protein. The removal of SUMO moieties from conjugated proteins by …
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Regulation of mGluR7 trafficking by SUMOylatio in neurons
Protein SUMOylation is a post-translationalmodification by which SmallUbiquitin-like MOdifier (SUMO) proteins are covalently linked to the lysine residues of target proteins via an enzymatic cascade. It has been reported that SUMOylation of synaptic proteins plays important regulatory roles in …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… modification of transcription factors by SUMO proteins represents an important mechanism through which their activity is controlled. Here, I also demonstrate that Gsc is sumoylated in mammalian cells by members of the PIAS family of proteins and this modification potentiates the repressive …
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Die Funktion von Geminin beim Übergang von Neuro- zu Gliogenese in der Maus
… Im Rahmen dieser Arbeit wurde mit der SUMOylierung eine bisher unbeschriebene posttranslationale Modifikation des Geminin-Proteins aufgezeigt. Die kovalente Anheftung des SUMO-Proteins vermag die Funktion von Geminin hinsichtlich des zellulären Kontext zu spezifizieren und zur …
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Targeting an E3 ubiquitin ligase Siah1 and a cysteine protease SENP1 using SPR and DSF-based fragment screening
… fragment screening studies against two human proteins Siah1 and SENP1, which function in post-translational modification pathways. Siah1 is an E3 ubiquitin ligase that functions as a scaffold to transfer ubiquitin bound to an E2 ubiquitin-conjugating enzyme to a substrate as part of the …