Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"SUMO Interacting Motifs (SIMs)"”.
-
Npsd4: A New Player In Sumo-Dependent Dna Repair
… of post-translational modifications, including SUMOylation. Through proteomic analysis of proteins involved in SUMOylation following DNA damage, our lab identified an uncharacterized protein that we named New Player in SUMO-dependent DNA damage repair 4 (NPSD4). Through an additional proteomic …
-
Host Proteins Interact with the Hiv-1 Core to Facilitate and Restrict
… HIV-1. Additionally, in AIM 2 I demonstrate that SUMO-1 and SUMO interacting motifs (SIMs) are important for TRIM5á restriction of HIV-1 and TRIM5á stability.</p><p>As mentioned before, the viral capsid is the determinant of TRIM5-mediated restriction. The capsid houses the viral RNA and other …
-
Understanding The Role of Sumoylation In Regulating Lkb1 Function
… in governing LKB1 activity. However, the role of SUMOylation in regulating LKB1 function is unknown. SUMOylation is the reversible covalent modification of a SUMO (small ubiquitin-related modifier) protein to a specific lysine on the target protein. This process has been implicated in important …