Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"SUDEP"”.
-
Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden Unexpected Death in Epilepsy (SUDEP) causes significant mortality in epilepsy, affecting 1:1000 people every year. Preceding SUDEP, patients experienced a final GTC seizure, transient apneas and bradycardia, culminating in terminal apnea and asystole. Failure to recover from postictal …
-
NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)
… and sudden unexpected death in epilepsy (SUDEP) is second only to stroke in the years of potential life loss among the major neurological disorders. In the majority of observed human SUDEP cases, respiratory dysfunction post-seizure is shown to be the primary initiating event leading to …
-
Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… at risk for Sudden Unexpected Death in Epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kv1.1 knockout (KO) mice, a model of temporal lobe epilepsy and SUDEP. We reported respiratory abnormalities in KO mice using the methacholine (MCh) challenge, …
-
Metabolomica: un nuovo approccio per lo studio della predittività di farmacoresistenza e di complicanze cardiovascolari in epilessia
… treatments. The risk of sudden unexpected death (SUDEP) is more than 20 times higher in epileptic patients than that in the general population; SUDEP represents the main cause of death in patients with refractory epilepsy. Several mechanisms probably exist, but most research has focused on seizure …
-
Continuous assessment of epileptic seizures with wrist-worn biosensors
… of sudden unexpected death in epilepsy (SUDEP) remains unclear. This thesis describes the development of a wearable electrodermal activity (EDA) and accelerometry (ACM) biosensor, and demonstrates its clinical utility in the assessment of epileptic seizures. The first section presents the …
-
Generation of focal Depdc5 knockout mouse model and implications for focal epilepsy
… risk of Sudden-Unexplained Death in Epilepsy (SUDEP). It remains unknown whether seizures due to DEPDC5 loss are a result of in utero cortical developmental defects or later neuronal dysfunction of mTORC1 signaling. To test this, we developed a postnatal adeno-associated virus (AAV) mediated …
-
Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… Project II: Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Transient apnea associated with Hypoxic-Hypercapnic (HH) conditions are recorded in patients who succumbed to SUDEP, suggesting a potential flaw in chemosensing mechanisms. …
-
Wireless tools for neuromodulation
… The tools are designed to study epilepsy, SUDEP, and urinary incontinence but can be configured for other studies. The broad application of these technologies can enable the scientific community to better study chronic diseases and closed-loop therapies.</p>