Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"STXBP1"”.
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Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that participate in the exocytotic process. First we show that SNAP25 is essential for cAMP-dependent rapid exocytosis in …
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… decreased expression of the exocytotic proteins STXBP1, SNAP25 and SYT11. In this paper I also made the novel observation that SYT11 increase basal insulin secretion and decrease rapid exocytosis, two phenomenons associated with T2D. The work on miR-335 emphasizes the importance of miRNAs in the …
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Understanding how deficits in sub- and higher- order cognitive processes impact problem-solving abilities in childhood
… individuals with a rare de novo mutation on the STXBP1 gene. This was the first study conducted in my PhD, which inspired my interest in understanding the processes involved in “intelligence”. It is presented as the last empirical chapter for coherence. Together, these studies highlight the …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… near interesting candidate genes: DISC1FP1 and STXBP1. Overlaps between transcribed nORFs, and SCZ- and BD-specific risk genes revealed nORFs to be enriched within SCZ- specific loci on chromosome 2. Functional predictions for the transcribed and translated nORFs revealed potential DNA-binding, …