Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"STRUCTURAL HOMOLOGY"”.
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Metalloprotein Design
… models with scaffolds bearing no sequence or structural homology to the modeled systems. Furthermore, this work demonstrates the usefulness of these models in understanding secondary coordination effects at the metal-binding sites within proteins and in introducing new activity into the …
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Genetic analysis and characterisation of the BapC autotransporter of bordetella pertussis
… proteins Pertactin, BrkA, Tcf, and Vag8 have structural homology at their C-termini (30-kDa) and the N-terminal of the mature proteins share structural characteristics such as RGD and SGXG motifs. Recently, another member of the B. pertussis autotransporter family, Bap-5 (Blackburn, 2000) …
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Protein structure recognition: from eigenvector analysis to structural threading method
… include the domain partition and a new structural threading method as well as the performance of this method in the CASP5 competition.;In the first part, we give a brief introduction to the protein folding problem. Some essential knowledge and progress from other research groups was …
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STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF MUCUS ADHESION PROTEINS OF LACTOBACILLUS REUTERI
… Lactobacillus species. However, knowledge on the structural or functional basis of adhesin interaction with mucin glycoproteins, the main component of mucus, is limited. This work describes the biochemical and structural properties of two cell-surface proteins from Lactobacillus reuteri, the …
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"Modernity's hearing loss" : Beethoven, romantic critique, and the music of the literary
… music and the literary, Chapter 4 suggests a structural homology between the novel, as paradigmatic form of literary modernity, and sonata form, as the main compositional strategy of the classical style. Both forms are seen as practices driven by a principle of openness toward difference that …
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Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus
… machinery and its members share sequence homology and structural and functional features. Higher eukaryotes express two members of this family Ctr1 and Ctr2. Numerous structural and functional studies are available for Ctr1, the only high affinity Cu(I) transporter thus far identified. …
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Structural and Functional Characterization of B. Anthracis Udp-Glcnac 2-Epimerase and Salmonella Secreted Effector I
<p>Structural biology has been an exceptionally powerful tool in the study of bacterial pathogenesis, not only in elucidating the molecular basis of disease as the first step towards the design of therapeutics but also in many cases leading to insights into hostpathogen biology that would not have …
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Viral and cellular proteins involved in vaccinia virus egress
… F12 and E2 also show no sequence or predicted structural homology to any other known proteins, and structural studies were performed in an attempt solve their 3D structure. The CRISPR-Cas9 targeted genome editing tool was also utilised to knockout different KLC isoforms in multiple cell lines …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… Gag region exhibits high levels of sequence and structural homology to IgG1 Fc and it could provide a key epitope important for auto-reactivity in RA. Analysis of how HERV-K10 may evoke immune responses in RA was broadened by investigation of serological cross-reactivity of novel anti-K10 …
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Structural studies of Butirosin D and FrbG
A structural homology model of Butirosin D is presented. This enzyme has been previously re-characterized as a deacetylase, releasing a free acetate molecule when acting upon the substrate 2’-N-acetylparomamine. The involved catalytic core residues within the model are 100% conserved, as compared …
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Using sequence data to investigate the functional design of proteins
… preserve a high degree of sequential and structural homology, yet are optimised by evolutionary processes to perform their specific function - assemble into widely diverse biological materials, such as fibrils or networks. The thesis exploits statistical modelling of protein sequence data …
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Studies on Combining Sequence and Structure for Protein Classification
… remote homologies that can be recognized by structural information. We hypothesized that combining evolutionary signals from protein sequence and 3D structure will improve automated protein classification. To test this hypothesis, we clustered proteins into evolutionary groups using both …
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
… predicted MW of 65 kDa. The lamins have several structural features that identify them as members of the family of intermediate filament proteins. Both lamins share an approximately 360 amino acid residue domain of α-helical conformation that, in turn, shows primary and secondary structural …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… and as such it shares both sequence and structural homology with proteins that are energy-dependent efflux transporters driven by ATP hydrolysis, making MDR1 a member of the ATP binding cassette (ABC) super family. Because, MDR1 transports substrates that are often toxic xenobiotics, MDR1 …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… and as such it shares both sequence and structural homology with proteins that are energy-dependent efflux transporters driven by ATP hydrolysis, making MDR1 a member of the ATP binding cassette (ABC) super family. Because, MDR1 transports substrates that are often toxic xenobiotics, MDR1 …
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Salmonella Suppress Innate Immunity by Targeting Mast Cells
… Tyrosine Phosphatase (SptP), which shares structural homology with <italic>Yersinia</italic> YopH. Interestingly, SptP, not only shares homology with phosphatases found in MCs, they are also homologous to YopH an effector protein expressed by plague causing <italic>Yersinia pestis</italic>. …
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Diverse functions of LanC-like proteins in mammalian cells
… dehydratase domain of LanM unexpectedly showed structural homology with mammalian kinases such as the mammalian target of rapamycin (mTOR). This finding has led us to look for potential interaction partners for LanCL proteins. In Chapter 2, I demonstrate that LanCL proteins physically interact …
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Structural and biochemical characterisation of pUL7 and pUL51, conserved tegument proteins required for efficient herpesvirus assembly
… pUL7 nor pUL51 share appreciable sequence-level homology with any protein of known function, which has frustrated attempts to infer their function by analogy. Since viral proteins can exhibit structural homology to other proteins in the absence of appreciable sequence conservation, the pUL7:pUL51 …
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A 3-dimensional vascularized cardiac tri-culture model using chitosan nanofiber scaffolds
… Chitosan, a natural polysaccharide that shares structural homology to the ECM glycosaminoglycans was processed into nanofibers via electrospinning to resemble the physical nano-architecture of the ECM. The second aim was to biologically modify the scaffold using a two step method: (1) Adsorption …
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… formation and natural product formation. Structurally, bacterial polyprenyl transferases can be categorized into eight groups: αcyclase, α, αβ, αβγ, βγ, ε, ζ and TIM barrel fold proteins. Six bacterial polyprenyl transferases were investigated in the current research, including …
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