Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"STK11"”.
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB) for unknown reasons. We found that introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 (KP) resulted in …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
… in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor implicated in lung and cervical cancers. Stk11 loss resulted in disassembly of the primary cilium, a cellular organizing center for Hh pathway components, thus dampening Hh signaling. Loss of Stk11 also …
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Γενετική ανάλυση στον κληρονομικό καρκίνο του μαστού
… (BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C) με την χρήση τεχνολογίας αλληλούχισης επόμενης γενεάς. Για το σκοπό αυτό αναλύθηκαν 42 ασθενείς με σοβαρό ιστορικό καρκίνο μαστού ή/και ωοθηκών, οι οποίες είχαν …
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Investigating Novel Targets to Inhibit Cancer Cell Survival
… regulating protein serine-threonine kinase 11 (STK11). Because of the unique role that Linc00467 serves in regulating autophagy we renamed it as, autophagy regulating long intergenic noncoding RNA or ARLINC. Taken together the work in this dissertation unveils the inner-workings of two important …
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Tumour Associated Neutrophils as a Potential Biomarker for Anti-PD-1 Immunotherapy in Non-Small Cell Lung Carcinoma: An Automated Approach
… in males, patients with smoking history, STK11 mutations, and a near absence of EGFR mutations. Proteomic analysis revealed upregulation of potentially targetable neutrophil proteins (MMP9, ARG1, ELANE, PADI4, S100A9). The automated TAN classifier achieved high accuracy (92.8%) and an AUC …
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Genetic Testing Uptake and Yield in Patients with Male Breast Cancer
… <em>RAD51C</em>, <em>RAD51D</em>, <em>STK11</em>, and <em>TP53</em>, and compare genetic testing uptake and yield of gPV in the clinically actionable genes for MBC: <em>BRCA1</em>, <em>BRCA2</em>, and <em>PALB2</em>, by age at diagnosis, race, and ethnicity, in a MBC cohort.</p> …
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In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… interacting protein 1), SLA (Src-like-adaptor), STK11 (serine/threonine kinase 11), WNKI (WNK lysine deficient protein kinase 1), and ZNF446 (zinc finger protein 446). This is the first in vivo genome-wide expression study on human B cells for osteoporosis. My results suggest a novel mechanism …
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Análisis pronóstico del perfil mutacional determinado por secuenciación de nueva generación en plasma en pacientes con cáncer de pulmón no microcítico metastásico
… TP53 (62%), seguida de NF1 (17%), KRAS (15%), STK11 (13%), EGFR (13%), CDKN2A (11%) y APC (10%). Las mutaciones no sinónimas en TP53 y KRAS se asociaron de forma independiente a peor supervivencia global (SG) (HR=1,76; IC 95% 1,08-2,86 y HR= 2,64; IC 95% 1,38-5,04, respectivamente). Los …
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Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… tuberous sclerosis complex (TSC1 and TSC2) and STK11 were identified as potential markers to duocarmycin analogues cytotoxicity.
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Comparación de perfiles de metilación de genes supresores tumorales en distintos subgrupos de tumores vesicales no músculo-invasivos
… El gen más frecuentemente metilado fue el STK11, presentando un porcentaje de metilación de 98,73% en TaBG, de 98,76% en T1BG y de 93,41 en T1AG para el un índice de metilación (IM) mayor de 0.3 y de 97.5%, 93.8% y 87.9, respectivamente, para IM>0.5. La metilación de varios GST fue …
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The Effects of 3-Phosphoglycerate and Other Metabolites on the Activation of AMP-Activated Protein Kinase by LKB1/STRAD/MO25
Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase, AMPKK. The LKB1-STRAD-MO25 complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This …