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Showing 1 to 8 of 8 for “"STING agonist"”.
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Tumor-Specific STING Agonist Synthesis via a Two-Component Prodrug System
Pharmacological activation of STING holds promise in cancer treatment. A recent trend is the development of tumor-specific or conditionally activated STING agonists for enhanced safety and efficacy. Herein, we explored an unconventional prodrug activation strategy for on-tumor synthesis of a potent …
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Delivery of sting agonist using lipid nanoparticles and discovery of anti-TIGIT peptides for cancer therapy
… above. The first research aims to deliver a STING agonist into a cold tumor using lipid nanoparticles. This delivery is intended to provoke an immune response that leads to the elimination of tumor cells. STING pathway agonism has shown promise in innate immune signaling to tune the tumor …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… with either chemotherapy or a single dose of a STING agonist in combination with PD-1 checkpoint blockade significantly suppressed tumor growth and extended overall survival. Taken together, these findings establish a pivotal endocrine-tumor network that links liver and tumor immunobiology …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
… component stimulator of interferon genes (STING) could reprogram tumor associated macrophages (TAMs) and myeloid derived suppressor cells (MDSCs) to support rather than suppress T cell activity, converting CRPC and PDAC to settings in which checkpoint blockade can be effective. To this end, …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… yet most patients remain unresponsive to existing therapies. The cGAS-cGAMP-STING pathway, a notable target, primarily activates the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor types. Immunologically "cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC), remain clinically unresponsive to …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… immunoadjuvants such as toll-like receptor (TLR) agonists, exosomes, and metallic immunoadjuvants have been studied for their immunological effects. However, the clinical use of immunoadjuvants is limited by transient responses and various side-effects. Therefore, there is a need for exploring …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.