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Showing 1 to 4 of 4 for “"STING Protein"”.

  1. The Role of the cGAS-STING Pathway in Cancer and Autoimmunity

    … activates the stimulator of interferon genes (STING) protein to induce type I interferons, inflammatory cytokines, and autophagy. The cGAS-STING pathway played a critical role in cancer immune surveillance by detecting tumor-derived DNA. Furthermore, stimulating the pathway using STING agonists …

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  2. The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation

    … yet most patients remain unresponsive to existing therapies. The cGAS-cGAMP-STING pathway, a notable target, primarily activates the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite …

    utswmed Repository record for The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation (opens in a new tab)