Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"STIM1"”.
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different cell types by sensing endoplasmic reticular Ca2+ levels and coupling to plasma membrane Orai channels. The role of STIM1 in heart is not well understood, given the robust Ca2+ regulatory …
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Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry
… which causes stromal interaction molecule 1 (STIM1) to accumulate at junctions between the ER and plasma membrane (PM). Within these membrane contact sites (MCS), STIM1 forms puncta that trap and activate Orai1 Ca2+ channels in the PM, allowing Ca2+ to flow into the cytoplasm and slowly …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
<p>Orai1 and STIM1 proteins are the essential components of the Ca<sup>2+</sup> release activated Ca<sup>2+</sup> (CRAC) channel which is required for store-operated Ca<sup>2+</sup> entry (SOCE) in T cells and subsequent signaling events leading to T cell activation, proliferation, and …
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STIM Protein Coupling Domains and The Activation of Orai Channels
STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca2+ sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane (PM) Orai Ca2+ channels. The coupling of STIM proteins and Orai Ca2+ entry channels generates “store-operated” Ca2+ …
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Pharmacological regulation and function of store-operated calcium channels
… existing in almost all types of mammalian cell. STIM1, ORAI and TRPC have been regarded as the molecular basis of SOCE. Once the endoplasmic reticulum (ER) Ca²⁺ store is depleted, STIM1 proteins move to the plasma membrane and activate ORAI and TRPC channels to allow Ca²⁺ influx. In this thesis, …
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Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model
… expressing the stromal interaction molecule 1 (STIM1) protein in the NG115-401L cell, which is also an ER localized protein that serves as a pivotal calcium influx channel regulator. NG115-40lL neurons present a native deficiency of STIM1 expression in a background phenotype with well …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… was shown that Stromal Interaction Molecule 1 (STIM1) inhibits plasma membrane Ca2+/ATPase 4 (PMCA4) function during T cell activation resulting in sustained elevation of Ca2+ signals(Ritchie, Samakai, & Soboloff, 2012). This interaction requires upregulation of both STIM1 and PMCA4. In this …
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Store-Operated Calcium Entry And Its Function During Fertilization In Porcine Eggs
… at fertilization. Previously we have shown that STIM1, a key component of the store-operated calcium entry pathway plays an important role in regulating the oscillatory Ca<sup>2+<sup> signal during porcine fertilization. …
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Studies of calcium signalling mechanisms in human platelets
… is known as store operated Ca2+ entry (SOCE). STIM1 is the Ca2+ sensing protein of the endoplasmic reticulum (ER) which activates Orai channels in the plasma membrane allowing Ca + entry. However, not all of the details of Ca2+ entry are understood. In platelets, two other pathways also enable …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… of the SOCE promoting machinery (i.e. Orai1/STIM1), a Ca2+-activated adenylyl cyclase (ADCY8), PKA and the A-kinase anchoring protein (AKAP79). Based on our findings, we suggest that inhibiting the actions of PDE1C may represent a valid novel therapeutic approach to decrease the burden …
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Remodelado de la entrada de calcio operada por los reservorios y su regulación por micrornas en la reestenosis vascular
… un incremento de la expresión de Orai1, STIM1 y Saraf en las arterias lesionadas por angioplastia. Además, demostramos una colocalización/interacción entre Orai1 y Saraf en la zona de la neoíntima que presenta una mayor proliferación celular. La inhibición de expresión de Orai1 y Saraf en …
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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
… dissertation" we" present" an" evidence" that" STIM1/Orai1" plays" an" important" role" in" MRGPRX2" mediated" calcium" influx" and" mediators"release"when"stimulated"with"LLE37"and"SP."" Moreover,"this"dissertation"showed"naturally"occurring"missense"mutations" of" MRGPRX2" both" within" and" …
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
… in a ternary complex with mediators of SOCE, STIM1 and ORAI1. These results explain the CaCC-enhancing effects of CLCA family members and suggest a broader role in other calcium-dependent processes. Understanding the modulatory relationship between these molecules may lead to better therapies …
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The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
Pancreatic acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …