Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"STAT6"”.
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Stat6-vermittelte Genregulation in eukaryontischen Zellen
Der Transkriptionsfaktor Stat6 vermittelt zentrale Wirkungen von IL-4 und IL-13, die in der Pathologie atopischer Erkrankungen eine Rolle spielen. Seine Spezifität für diese beiden allergieassoziierten Cytokine ist eine wesentliche Motivation ihn näher zu untersuchen. In dieser Arbeit sollte mehr …
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Regulation of STAT6 and STAT4 Phosphorlation by Histamine
… differentiation into Thl and Th2 respectively. STAT6 is activated in response to IL-4 and IL-13 whereas IL-12 activates STAT4. The activation of these STAT factors is an important step in the modulation of T lymphocytes balance. Histamine alters the Thl/Th2 cytokine balance towards the Th2 …
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Generation of mice expressing a constitutively active stat6: a model for the analysis of IL-4 signaling and tumor progression
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Spezifische Hemmung der allergieassoziierten Interleukin-4 Signaltransduktion
… des IL-4 aktivierten Transkriptionsfaktors Stat6 ist ein Schlüsselereignis bei der allergischen Immunantwort. In der vorliegenden Arbeit werden Ergebnisse zur Hemmung der Stat6 vermittelten Signaltransduktion des IL-4 Rezeptors vorgestellt. Dazu wurde ein Vektorsystem etabliert, bei dem ein …
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Transkriptionelle Regulation des CD23a-Promotors in Zellen chronischer lymphatischer Leukämien vom B-Zelltyp
… galt dabei putativen Bindungsstellen für STAT6. Das Bindungsverhalten von Transkriptionsfaktoren an Promotor-DNA wurde mit Gel-Retardierungsexperimenten (EMSA) untersucht. Hierzu wurden CD23a-Core-Promotor-Oligonukleotide zusammen mit Kernproteinextrakten aus Stimulationsansätzen von …
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
… regions. Mice with an activating mutation in STAT6, known as STAT6VT, constitutively express STAT6 in T-cells. Our preliminary data suggests significant differences between the STAT6VT transgenic mice from WT littermate controls treated with SLS. These findings correlate with evidence that …
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Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes
… and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 and the production of cytokines in phorbol-12-myristate-13-acetate (PMA)-stimulated promyelocytes is regulated by calcium calmodulin kinase …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… has been shown to protect β-cell viability via STAT6 signalling, and preliminary data suggested that Signal Regulatory Protein-α (SIRPα) also plays a vital part in this protective effect. However, the protective mechanisms by which SIRPα sustains β-cell viability are poorly understood. Recently, …
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Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and Interleukin-4 Receptors and their Roles in T Cell Proliferation
… PI 3-kinase⁄Akt as well as a distinct STAT, STAT6. The HT-2 mouse T cell line responds to both IL-2 and -4. We found that IL-4 initially antagonizes, and later synergizes with, IL-2-stimulated HT-2 cell proliferation in a dose-dependent manner. IL-4 also stimulates cell adhesion in static …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… To address this gap, complementary NFκB-luc2 and STAT6-luc2 reporter mouse models were implemented to enable real-time monitoring of pro-inflammatory pathway and Th2 immune response. A novel STAT6-luc2 reporter line was generated and validated to this purpose. When combined with the established …
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Role of microRNA-155 in dendritic cells and macrophages: MiR-155 directly targets PU.1 and IL13Rα1
… and that IL-13 signalling cascade through STAT6 transcription factor was down regulated when miR-155 was over expressed. Using Anti miR-155 transfections in DCs, miR-155 was shown to modulate not only DC-SIGN expression, but also DC pathogen binding ability. Using the same technique in …
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Protektiver Effekt von 6-Shogaol, Ellagsäure und Myrrhe auf die intestinale epitheliale Barriere
… hemmen. Diese Arbeit zeigt, dass auch STAT6 an dem Claudin-2-Expressionsanstieg durch TNF-α in HT-29/B6-Zellen beteiligt ist. So wurde durch Myrrhe die TNF-α-induzierte Phosphorylierung von STAT6 und die erhöhte Claudin-2-Expression inhibiert. Die Ergebnisse deuten darauf hin, dass die …
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Differentielle Genexpression in der Insulinoma-Zelllinie RINm5F nach Stimulation mit Leptin
… range of STAT factors (STAT1, STAT3, STAT5 and STAT6). In contrast, IL6 and GH only induced tyrosine phosphorylation of a smaller subset of STAT factors (STAT5 and STAT6 with GH; STAT1 and STAT3 with IL-6). Leptin treatment also led to the phosphorylation of the serine residue 727 in STAT3 and …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… the mediation of the transcription factor STAT6, subsequently accelerating the growth and migration of IBC cells. Intriguingly, CIBERSORT deconvolution showed that high AXL expression is correlated with an immunosuppressive TME, including the larger population of M2 macrophages, in tumor …
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Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion
… durch Genexpressionsanalysen Zielgene von STAT6 im cHL identifiziert und teilweise validiert werden. Unter diesen Genen sind vor allem der Transkriptionsfaktor IRF4, die IL-13-Rezeptoruntereinheit IL13Ra1, die Rezeptortyrosinkinase EphB1 und die Proteinphosphatase PTPRK zu erwähnen. Diese …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… of multiple STATs (STAT1, STAT3, STAT5, and STAT6), with STAT3 showing the highest level of activation. Therefore, we further investigated STAT3 activation dynamics and effects of its inhibition on infection. STAT3 phosphorylation and nuclear translocation were detected beginning 48 h …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β signaling pathways, produce IL-9 as a hallmark cytokine, as well as IL-10. Through IL-9 production, Th9 cells protect against parasite infection but are also involved in allergic inflammation and autoimmune diseases. Transcription …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… IL-4 and IL-13, drive M2 differentiation via STAT6 signaling, whereas IL-10 suppresses inflammation via STAT3 and enhances M2 marker expression. As these cytokines often coexist in chronic inflammation, we investigated whether their combined action promotes a more stable M2 phenotype than …
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Roles for the E3 Ligase Itch in Immune Response Modulation
… modulation of Th2 differentiation occurs in a Stat6 dependent pathway. Itch fl/fl CD4 Cre Stat 6 -/- CD4+ T cells were found to be incapable of differentiating into Th2 cells in vitro. Itch fl/fl CD4 Cre Stat 6 -/- did not develop spontaneous inflammation disease, underscoring the 1 ST-T …
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