Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"STAT3 inhibition"”.
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Role of Stat3 In Human Nk Cell Functions
… IL-21 (mbIL-21), which predominantly activates STAT3, induce robust expansion and activation of human NK cells. Further investigations revealed role of STAT3 in the transcriptional regulation of NKG2D, a primary activating NK receptor. Based on these findings, I hypothesized that STAT3 signaling …
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Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… protection against bacterial pathogens requires STAT3 activation. We hypothesize here that STAT3 activation is also required for Pam2ODN-induced protection against the influenza A virus (IAV).</p> <p> In our in-vitro model, human bronchial epithelial cells (HBEC3-kt) were treated with STAT3 …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… mice following endotoxin administration. NF-κB inhibition attenuated the impact of endotoxin on transporter expression, suggesting that NF-κB is the major signaling pathway involved in endotoxin-mediated downregulation of hepatic transporter, and it appears to act independent of PXR. Conversely, …
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Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells
… HGF expression, which was reversed upon ∆EGFR inhibition with AG1478. ∆EGFR required c-Met to maintain elevated HGF expression, colony formation of glioblastoma cells, and the tumorigenicity of orthotopic xenografts. An unbiased mass spectrometry-based approach identified …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and signal transducer and activator of transcription (STAT) 3 and STAT5 are dephosphorylated and inactivated. Following sustained Src inhibition, STAT5 remains inactive, but Jak2 and STAT3 are reactivated following …
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A next generation theranostic nano-platform for sustained and enhanced inhibition of cancer stem cells
… transducer and activator of transcription 3 (STAT3). The aberrant activity of STAT3 has been identified in clinical inspection of > 70% of breast and prostate cancer and its inhibition by various mechanisms holds unprecedented significance in modern medicine. Niclosamide (Nic), an FDA approved …