Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"STAT2"”.
-
Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… and activator of transcription 1 (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. …
-
Regulation of type I interferons in murine dendritic cells
… Transducer and Activator of Transcription 2 (STAT2) and Three prime Repair EXonuclease 1 (Trex1), in DC biology. Our research furthers our understanding of DC development, activation and function, and provides important data for the therapeutic application of modified DCs to induce …
-
Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
… transducer of activator of transcription-2 (STAT2) protein may display a similar defect in T cell receptor mediated IL-2 expression. IFNAR2 knockout and STAT2 knock-in splenocytes may display a defect in IL-2 mRNA expression as early as twelve hours post-stimulation. However, IL-2 promoter …
-
Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… overexpression of proteins including EGFR, STAT2 and EPS8L2 across all grades, as well as the aberrant activation of the PI3K/AKT/mTOR pathway. Further, we validated upregulation in all grades of the total and activated phosphorylated form of the NIMA-related kinase, NEK9, involved in …
-
Investigating the immune response to central nervous system invasion by Brucella
… its receptors, IFN-a receptors, STAT1, and STAT2 all play crucial, interconnected protective roles in the development of disease. Our findings described here reveal numerous previously unknown characteristics of the immune response to CNS invasion by Brucella that have helped advance the …
-
Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… of nsp6 to block phosphorylation of STAT1 and STAT2 in vitro compared to WA1 nsp6, thereby suppressing the IFN-I signaling pathway. Furthermore, ΔSGF-WA1 infection of primary airway cultures secretes similar levels of infectious virus and viral RNA than WA1-infected cells but produces higher …
-
Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… This was dependent upon recruitment of STAT2 to a consensus cluster of IRF motifs (IRF3/7/9, termed the IRFC) located ~200bp upstream of the Clec2d TSS. Clec2d induction by type-I IFN was IRF9- and STAT1-dependent, abrogated in IRF9–/– or STAT1–/– MEF or upon mutation of the IRFC. Thus, …
-
Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… cytokine pathways, acting via STAT1 and STAT2, contribute to β-cell death whereas anti-inflammatory mechanisms (operating via cytokines such as Interleukin-13 (IL-13)) are downregulated. IL-13 has been shown to protect β-cell viability via STAT6 signalling, and preliminary data suggested …
-
Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… analysis identified key pathways, including EGFR-STAT2, interferon alpha/beta signaling activation, and anti-apoptotic signaling upon EGFR induction; KRAS-CDX2 regulation and epithelial homeostasis dysregulation upon KRAS induction; and CTNNB1 to KRAS regulation upon CTNNB1 induction. Some of …
-
The Biology of Dendritic Cells in the Context of Autoimmunity
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects at least five million people worldwide. An increased expression of type I interferon (IFN) regulated genes is a hallmark of SLE, but the precise etiology of SLE initiation and flares is poorly understood. Because …