Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"STAT1"”.
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Cut out for the job: how FAM111A regulates STAT1 and magnesium homeostasis
Contains fulltext : 313557.pdf (Publisher’s version ) (Open Access)
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A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
… type II IFN-induced signalling. Cellular protein STAT1, a crucial protein required for IFN-induced signal transduction, was identified as a direct binding partner of 018. Mapping experiment identified the SH2 domain of STAT1, a region important for STAT1 recruitment to IFN-receptors, as the site …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… transducer and activator of transcription 1 (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune …
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Signal specificity amongst STAT1- and STAT3- inducing cytokines in the context of Th17 differentiation
… systematically characterizing the activation of STAT1 and STAT3 by IL-6, IL-10, IL-21, IL- 27, and different combinations of cytokines in CD4+ T cells. In this analysis we find that the ratio of STAT3 to STAT1 activated is the important quantity in determining whether or not a cytokine will be an …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… transducer and activator of transcription 1 (STAT1) is activated in response to interferon signalling and upregulates cytokines responsible for the recruitment of TILs to the TME. Building on previous findings linking STAT1 expression to a pre-existing immunoreactive TME and improved clinical …
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Priming of STAT1 and STAT3 for cytokine-triggered degradation by the proteasome upon A2Aadenosine receptor (A2AAR) expression
… blocked by preincubation with JAK inhibitor. B) STAT1 but not STAT3 was resistant to both tyrosine phosphorylation and down-regulation in response to leptin and C) a Tyr705→Phe mutated STAT3 was also resistant to cytokine-triggered degradation, suggesting that JAK-mediated phosphorylation of this …
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DJ-1, a Parkinson’s Disease-associated Gene, Prevent Excessive Glial Inflammatory Responses through Interaction with SHP-1
… by facilitating the interaction between STAT1 and its phosphatase, SHP-1 (Src-homology 2-domain containing protein tyrosine phosphatase-1). Astrocytes and microglia cultured from DJ-1-knockout (KO) mice exhibited increased expression of inflammatory mediators and phosphorylation levels of …
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Signal Transducer and Activator of transcription-1 (STAT-1) und STAT-1 assoziierte Proteine (MCM3,MCM5) in epithelialen Ovarialkarzinomen : Expressionsanalysen und Prognostische Relevanz
… transducer and activator of transcription-1“ (STAT1) und STAT1-assoziierter Moleküle („minichromosome-maintenance“: MCM-3, -5) in epithelialen Ovarialkarzinomen des Stadiums IIIc zu untersuchen und auf ihren prognostischen Wert hin zu überprüfen. <br>Dazu wurde auf RNA- und Protein-Ebene die …
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was designed to determine the role of histamine in the regulation of ST ATI …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… in epithelial tumorigenesis, but the role of Stat1 is largely unknown. The current study was designed to explore the role of Stat1 during multistage skin carcinogenesis. Topical treatment with both TPA and the anthrone derivative chrysarobin (CHRY) led to rapid phosphorylation of Stat1 on both …
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Inactivation of the JAK-STAT Pathway
… cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 minutes, remained for 2-2.5 hours and activated molecules disappeared by 4 hours. In the absence of continued signaling from the IFN-γ receptor (imposed by staurosporine treatment) previously activated …
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Modulation of innate immune signaling pathways by the intracellular pathogen Toxoplasma gondii
… Toxoplasma activates NF-[kappa]B and inhibits STAT1 signaling pathways to promote both its own survival and the survival of its host. We identified GRA15, a novel Toxoplasma secreted factor that activates the host cell NF-[kappa]B pathway. GRA15 is polymorphic between Toxoplasma strains and …
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TARGETING COCHLEAR INFLAMMATION FOR THE TREATMENT OF CISPLATIN OTOTOXICITY
… transducer and activator of transcription 1 (STAT1) a transcription factor implicated in inflammation, which mediates damage to utricular hair cell and could also confer cisplatin-induced hearing loss. The aim of this study is to further define a role of STAT1 in cochlear inflammation and in …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… and proteomic approaches. This work identified STAT1 as a mediator of iCAF-induced transcriptional reprogramming. STAT1 was found to associate with accessible chromatin regions and to co-occupy a subset of sites with FOXA1/FOXA2, promoting expression of interferon (IFN)-α/γ response genes. …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… in colitis Socs1ΔIEC mice seems driven by STAT1-dependent sensitization of Socs1- null IECs to apoptosis induced by immune cells-derived IFNγ in response to bacterial invasion. To define SOCS1 IEC-intrinsic role in the epithelium integrity and renewal, and for confirming that SOCS1 …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… that IFN-γ and IFN-γ + TNF-α induced JAK1/2-STAT1 signalling followed a dose-to-duration pattern of activation whereby increasing concentration of cytokines resulted in sustained JAK-STAT signalling leading to epithelial cell death. This dose-to-duration signalling pattern allowed cells to …
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