Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"STAT-1"”.
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Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
… transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was designed to determine the role of histamine in the regulation of ST ATI …
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Signal Transducer and Activator of transcription-1 (STAT-1) und STAT-1 assoziierte Proteine (MCM3,MCM5) in epithelialen Ovarialkarzinomen : Expressionsanalysen und Prognostische Relevanz
… transducer and activator of transcription-1“ (STAT1) und STAT1-assoziierter Moleküle („minichromosome-maintenance“: MCM-3, -5) in epithelialen Ovarialkarzinomen des Stadiums IIIc zu untersuchen und auf ihren prognostischen Wert hin zu überprüfen. <br>Dazu wurde auf RNA- und Protein-Ebene die …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
… IFN-g, we investigated the effect of IFN-g- or Stat-1-deficiency during T. cruzi infection. Surprisingly, IFN-g did not have a major role in up-regulating T-bet or for suppressing the development of Th17 responses, whereas Stat-1 was necessary for both. This was unexpected as Stat-1 is an …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… TNF-, and IL-6, and this induction depends on STAT-1 transcription factor. Additionally, we have observed that ATF3 weakly binds to the CH25H promoter, suggesting co-operation with STAT-1. However, ZIKV induced CH25H was independent of type I interferon. Conclusion This study has demonstrated …
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Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of signal transducer and activator of transcription 1 (STAT-1), from which its name is derived. PIAS1 facilitates STAT-1 …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… kinases as well as their phosphorylated form (STAT 1, P-STAT 1, STAT 3, P-STAT-3, JAK 1, P-JAK 1, JAK 2, P-JAK 2, Ras GAP and JNK 1) were investigated by means of western blot analysis and western blot analysis after immunoprecipitation in wild type HepG2 cells as well as TIMP-1 overexpressing …
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Astrocytes down-regulate microglial inflammatory responses
… Therefore, I examined how astrocytes in injury states modulate microglial activation. Astrocytes were treated with oxygen-glucose deprivation (OGD) or hydrogen peroxide (H₂O₂, 0.01-1 mM), and culture conditioned media (OGDACM or H₂O₂-ACM) were collected. Both OGD-ACM and H₂O₂-ACM collected …
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Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… mediated by preventing the translocation of STAT-1 to the nucleus, thus preventing an increase in the level IRF-7 expression, which is required for optimal IFN-a production by PDC. The extent of the subversive effect of PRRSV on the activation of PDC was further appreciated by transcriptional …