Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"STAT transcription factors"”.
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The regulation of the oncogenic STAT transcription factors by the non receptor tyrosine kinase and Cdc42 effector ACK
… relationships with the androgen receptor in prostate cancer and the oestrogen receptor in breast cancer, ACK regulates transcriptional networks in disease. In this work, new roles for ACK in transcription, mediated by its relationship with the signal transducer and activators of transcription …
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Differentielle Genexpression in der Insulinoma-Zelllinie RINm5F nach Stimulation mit Leptin
… islets. Leptin signals through the JAK/STAT pathway which is also used by other cytokines such as interleukin-6 (IL-6) or growth hormone (GH). Activation of this pathway leads to phosphorylation of STAT transcription factors which migrate into the nucleus and regulate gene expression. …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… Expression of SOCS3 is induced via the STAT transcription factors, and it exerts its inhibitory effect via interaction with the phosphorylated Y759 motif within the cytoplasmic region of the common receptor chain of all IL-6 type cytokines, gp130. Thereby SOCS3 colocalizes with the …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (IL-6) receptor gp130 in hepatocytes was investigated in terms of liver regeneration, liver dependent iron homeostasis and gram positive sepsis. …
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
… cues such as cytokines with cell intrinsic transcription factors, thereby promoting the necessary gene profile. Moreover, the observation that T-helper cells could exhibit a flexible nature (i.e having shared gene profiles and effector functions) not only demonstrate the efficiency of our …
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Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… in the form of cytokines, and downstream transcriptional networks responsible for promoting the unique gene expression profile for each subset while simultaneously suppressing alternative cell fates. However, the exact composition of, and stage-specific requirements for, these …